C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H

Status	Only small colony available
EMMA ID	EM:16316
Citation information	RRID:IMSR_EM:16316 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
Alternative name	HEPD0678_4_A08
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Golga3^{tm1b(EUCOMM)Hmgu}
Gene/Transgene symbol	Golga3
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Mary Lyon Centre at MRC Harwell
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0678_4_A08. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

male infertility / IMPC
decreased hemoglobin content / IMPC
increased circulating alanine transaminase level / IMPC
increased circulating alkaline phosphatase level / IMPC
impaired glucose tolerance / IMPC
increased circulating aspartate transaminase level / IMPC

IMPC phenotypes (gene matching)

increased circulating alanine transaminase level / IMPC
male infertility / IMPC
decreased hemoglobin content / IMPC
increased circulating alkaline phosphatase level / IMPC
impaired glucose tolerance / IMPC
increased circulating aspartate transaminase level / IMPC

MGI phenotypes (gene matching)

impaired fertilization / MGI
abnormal testis morphology / MGI
small testis / MGI
abnormal spermatogenesis / MGI
male infertility / MGI
abnormal spermiogenesis / MGI
asthenozoospermia / MGI
globozoospermia / MGI
oligozoospermia / MGI
decreased testis weight / MGI
decreased male germ cell number / MGI
azoospermia / MGI
reproductive system phenotype / MGI
teratozoospermia / MGI
abnormal male germ cell apoptosis / MGI
absent sperm flagellum / MGI
detached sperm flagellum / MGI
abnormal sperm head morphology / MGI
decreased fertilization frequency / MGI

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Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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