C57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16323
Citation informationRRID:IMSR_EM:16323 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H
Alternative nameHEPD0727_4_A06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCdc42tm1b(EUCOMM)Hmgu
Gene/Transgene symbolCdc42
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0727_4_A06. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome / Orphanet_487796
    • Neonatal-onset severe multisystemic autoinflammatory disease with increased IL18 / Orphanet_619363
IMPC phenotypes (allele matching)
  • abnormal cranium morphology / IMPC
  • corneal opacity / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • enlarged kidney / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased circulating serum albumin level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating serum albumin level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • enlarged kidney / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • corneal opacity / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating aspartate transaminase level / IMPC
MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • decreased embryo size / MGI
  • no abnormal phenotype detected / MGI
  • disorganized embryonic tissue / MGI
  • decreased ventricle muscle contractility / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • absent embryonic epiblast / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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