C57BL/6N-Elovl6tm1b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16362
Citation informationRRID:IMSR_EM:16362 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Elovl6tm1b(EUCOMM)Hmgu/H
Alternative nameHEPD0729_3_F04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolElovl6tm1b(EUCOMM)Hmgu
Gene/Transgene symbolElovl6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0729_3_F04. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased exploration in new environment / IMPC
  • limb grasping / IMPC
  • increased circulating triglyceride level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating amylase level / IMPC
  • increased red blood cell distribution width / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • increased circulating alkaline phosphatase level / IMPC
  • limb grasping / IMPC
  • increased circulating triglyceride level / IMPC
  • increased red blood cell distribution width / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating amylase level / IMPC
  • decreased exploration in new environment / IMPC
MGI phenotypes (gene matching)
  • abnormal liver morphology / MGI
  • abnormal lipid homeostasis / MGI
  • hepatic steatosis / MGI
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • enhanced coordination / MGI
  • increased lean body mass / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal pancreatic islet morphology / MGI
  • abnormal fatty acid level / MGI
  • improved glucose tolerance / MGI
  • growth/size/body region phenotype / MGI
  • decreased circulating leptin level / MGI
  • abnormal hepatocyte physiology / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • decreased fatty acid oxidation / MGI

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Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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