IMPC phenotypes (gene matching)
C57BL/6NTac-Gckem2(IMPC)H/H
| Status | Only small colony available |
| EMMA ID | EM:16388 |
| Citation information | RRID:IMSR_EM:16388 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Gckem2(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Gckem2(IMPC)H |
| Gene/Transgene symbol | Gck |
Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
- MODY / Orphanet_552
- Permanent neonatal diabetes mellitus / Orphanet_99885
MGI phenotypes (gene matching)
- abnormal circulating cholesterol level / MGI
- hypoglycemia / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- abnormal circulating insulin level / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- decreased circulating insulin level / MGI
- decreased insulin secretion / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased glycogen level / MGI
- increased circulating glucose level / MGI
- decreased circulating glucose level / MGI
- increased glycosylated hemoglobin level / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased glucokinase activity / MGI