FVB;129P2-Brca2tm1Brn/Cnrm
Status | Available to order |
EMMA ID | EM:01642 |
International strain name | FVB;129P2-Brca2tm1Brn/Cnrm |
Alternative name | Br2F |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Brca2tm1Brn, |
Gene/Transgene symbol | Brca2 |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Insertion of loxP sequences at the 5' and 3' of exon 11 in Brca2 gene. |
Phenotypic information | Conditional Brca2 knock-out; no phenotype. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary breast and ovarian cancer syndrome / Orphanet_145
- Fanconi anemia / Orphanet_84
- Inherited cancer-predisposing syndrome due to biallelic BRCA2 mutations / Orphanet_319462
- Cholangiocarcinoma / Orphanet_70567
Literature references
- Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.;Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A, ;2001;Nature genetics;29;418-25; 11694875
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