C57BL/6NTac-Col1a2em1H/H

Status

Only small colony available

EMMA IDEM:16420
Citation informationRRID:IMSR_EM:16420 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Col1a2em1H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCol1a2em1H
Gene/Transgene symbolCol1a2

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased bone mineral density / IMPC
  • decreased grip strength / IMPC
  • enlarged spleen / IMPC
  • decreased mean platelet volume / IMPC
  • abnormal tibia morphology / IMPC
  • increased bone mineral content / IMPC
  • dilated heart left ventricle / IMPC
  • increased large unstained cell number / IMPC
  • abnormal optic disk morphology / IMPC
  • increased neutrophil cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal femur morphology / IMPC
  • enlarged heart / IMPC
  • decreased blood urea nitrogen level / IMPC
  • increased leukocyte cell number / IMPC
  • decreased circulating amylase level / IMPC
  • increased heart weight / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased total body fat amount / IMPC
MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • decreased compact bone thickness / MGI
  • kyphosis / MGI
  • scoliosis / MGI
  • abnormal forelimb morphology / MGI
  • abnormal dermal layer morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal gait / MGI
  • hemorrhage / MGI
  • abnormal skin morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal caudal vertebrae morphology / MGI
  • abnormal bone mineralization / MGI
  • abnormal joint morphology / MGI
  • decreased tendon stiffness / MGI
  • abnormal long bone morphology / MGI
  • abnormal compact bone morphology / MGI
  • decreased bone strength / MGI
  • cellular phenotype / MGI
  • abnormal tendon morphology / MGI
  • decreased bone mineral content / MGI
  • decreased bone trabecula number / MGI
  • decreased bone volume / MGI
  • decreased compact bone area / MGI
  • abnormal compact bone lamellar structure / MGI
  • perinatal lethality, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • camptomelia / MGI
  • increased volumetric bone mineral density / MGI
  • increased osteocyte number / MGI
  • abnormal knee joint morphology / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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