MGI phenotypes (allele matching)
B6;129P2-Gja10tm1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:01644 |
| International strain name | B6;129P2-Gja10tm1Kwi/Cnrm |
| Alternative name | Cx57 LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gja10tm1Kwi, |
| Gene/Transgene symbol | Gja10 |
Information from provider
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Instead of the whole open reading frame of exon 2 (and 3), a lacZ reporter gene and a neomycin selection cassette is inserted in the Gja10 (Cx57) locus, leading to the expression of lacZ under the control of the endogenous Gja10 promoter. |
| Phenotypic information | Strong reduction of tracer coupling in horizontal cells of the retina. |
| Breeding history | After blastocyst-injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than 2 times. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
Literature references
- Functional expression of connexin57 in horizontal cells of the mouse retina.;Hombach Sonja, Janssen-Bienhold Ulrike, Söhl Goran, Schubert Timm, Büssow Heinrich, Ott Thomas, Weiler Reto, Willecke Klaus, ;2004;The European journal of neuroscience;19;2633-40; 15147297