IMPC phenotypes (allele matching)
C57BL/6NTac-Ccr2em1(IMPC)H/H
| Status | Only small colony available |
| EMMA ID | EM:16447 |
| Citation information | RRID:IMSR_EM:16447 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Ccr2em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ccr2em1(IMPC)H |
| Gene/Transgene symbol | Ccr2 |
Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal trabecular bone morphology / MGI
- decreased neutrophil cell number / MGI
- decreased monocyte cell number / MGI
- altered response to myocardial infarction / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- weight loss / MGI
- retinal degeneration / MGI
- abnormal osteoclast physiology / MGI
- hepatic necrosis / MGI
- multifocal hepatic necrosis / MGI
- liver inflammation / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- decreased airway responsiveness / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage morphology / MGI
- increased IgG level / MGI
- alcohol aversion / MGI
- abnormal monocyte morphology / MGI
- abnormal immune serum protein physiology / MGI
- abnormal conditioned taste aversion behavior / MGI
- increased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased tumor growth/size / MGI
- increased alcohol consumption / MGI
- decreased alcohol consumption / MGI
- abnormal leukocyte adhesion / MGI
- abnormal microglial cell physiology / MGI
- impaired macrophage chemotaxis / MGI
- decreased macrophage cell number / MGI
- increased hepatocyte apoptosis / MGI
- liver hemorrhage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- abnormal osteoclast cell number / MGI
- decreased osteoclast cell number / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- abnormal wound healing / MGI
- diarrhea / MGI
- decreased acute inflammation / MGI
- decreased T cell proliferation / MGI
- abnormal optic choroid morphology / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal cholesterol homeostasis / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal podocyte morphology / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- decreased circulating creatinine level / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- retinal deposits / MGI
- abnormal choriocapillaris morphology / MGI
- abnormal urine protein level / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased dendritic cell number / MGI
- abnormal osteoclast differentiation / MGI
- retinal photoreceptor degeneration / MGI
- retinal outer nuclear layer degeneration / MGI
- increased susceptibility to induced colitis / MGI
- decreased susceptibility to induced colitis / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased common myeloid progenitor cell number / MGI
- lipofuscinosis / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased splenocyte proliferation / MGI
- increased trabecular bone thickness / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
- decreased susceptibility to bone fracture / MGI
- abnormal bone mineral density / MGI
- abnormal dendritic cell chemotaxis / MGI
- abnormal macrophage chemotaxis / MGI
- abnormal bone trabecula morphology / MGI
- increased trabecular bone volume / MGI
- increased fluid intake / MGI
- increased CD11b-high dendritic cell number / MGI
- decreased CD11b-high dendritic cell number / MGI
- impaired leukocyte tethering or rolling / MGI