FVB.129P2-Brca1tm1Brn/Cnrm
Status | Available to order |
EMMA ID | EM:01645 |
International strain name | FVB.129P2-Brca1tm1Brn/Cnrm |
Alternative name | Br1F |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Brca1tm1Brn, |
Gene/Transgene symbol | Brca1 |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Insertion of 5' (intron 4) and 3' (intron 13) loxP sites in the Brca1 gene, by homologous recombination in ES cells. |
Phenotypic information | None. |
Breeding history | 6 generations backcrossed on FVB/N. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Fanconi anemia / Orphanet_84
- Hereditary breast and ovarian cancer syndrome / Orphanet_145
- Cholangiocarcinoma / Orphanet_70567
Literature references
- Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.;Clark-Knowles Katherine V, Garson Kenneth, Jonkers Jos, Vanderhyden Barbara C, ;2007;Experimental cell research;313;133-45; 17070800
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