C57BL/6NTac-Hrem1(IMPC)H/H

Status

Only small colony available

EMMA IDEM:16488
Citation informationRRID:IMSR_EM:16488 

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International strain nameC57BL/6NTac-Hrem1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolHrem1(IMPC)H
Gene/Transgene symbolHr

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • increased neutrophil cell number / IMPC
  • abnormal coat/ hair morphology / IMPC
  • absent vibrissae / IMPC
  • abnormal vibrissa morphology / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating amylase level / IMPC
IMPC phenotypes (gene matching)
  • abnormal coat/ hair morphology / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased neutrophil cell number / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • abnormal vibrissa morphology / IMPC
  • decreased circulating amylase level / IMPC
  • absent vibrissae / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
MGI phenotypes (gene matching)
  • abnormal hair follicle morphology / MGI
  • distended hair follicles / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • short hair / MGI
  • loss of eyelid cilia / MGI
  • abnormal hair cycle / MGI
  • abnormal colon morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • deformed nails / MGI
  • long toenails / MGI
  • abnormal hepatocyte morphology / MGI
  • abnormal mammary gland morphology / MGI
  • absent mammary gland / MGI
  • abnormal sebaceous gland morphology / MGI
  • sebaceous gland atrophy / MGI
  • abnormal skin condition / MGI
  • flaky skin / MGI
  • shiny skin / MGI
  • thin skin / MGI
  • thick skin / MGI
  • translucent skin / MGI
  • skin ridges / MGI
  • wrinkled skin / MGI
  • skin lesions / MGI
  • skin hyperplasia / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • abnormal epidermis stratum corneum morphology / MGI
  • hyperkeratosis / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • dermal cysts / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • curly vibrissae / MGI
  • wavy vibrissae / MGI
  • loss of vibrissae / MGI
  • short vibrissae / MGI
  • abnormal eyelid morphology / MGI
  • Meibomian gland atrophy / MGI
  • abnormal nursing / MGI
  • abnormal coat appearance / MGI
  • decreased IgM level / MGI
  • abnormal thymus involution / MGI
  • eye inflammation / MGI
  • acanthosis / MGI
  • abnormal lactation / MGI
  • female infertility / MGI
  • increased leukemia incidence / MGI
  • abnormal skin morphology / MGI
  • abnormal hair growth / MGI
  • premature death / MGI
  • abnormal vibrissa morphology / MGI
  • abnormal lymph node secondary follicle morphology / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgG level / MGI
  • granulomatous inflammation / MGI
  • abnormal keratinocyte differentiation / MGI
  • glomerulonephritis / MGI
  • decreased ovulation rate / MGI
  • hair follicle degeneration / MGI
  • epidermal cyst / MGI
  • cochlear ganglion hypoplasia / MGI
  • thymus atrophy / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair follicle dermal papilla morphology / MGI
  • hairless / MGI
  • lymph node inflammation / MGI
  • thin hypodermis / MGI
  • decreased cochlear inner hair cell number / MGI
  • decreased cochlear outer hair cell number / MGI
  • absent cochlear hair cell stereocilia / MGI
  • absent linear vestibular evoked potential / MGI
  • decreased thymus weight / MGI
  • decreased T cell number / MGI
  • abnormal dermis reticular layer morphology / MGI
  • decreased T cell proliferation / MGI
  • abnormal Meibomian gland morphology / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • loose skin / MGI
  • increased macrophage cell number / MGI
  • thick eyelids / MGI
  • thin retinal ganglion layer / MGI
  • thin retinal inner plexiform layer / MGI
  • abnormal vibrissa number / MGI
  • progressive hair loss / MGI
  • hypergranulosis / MGI
  • epidermis stratum granulosum hyperplasia / MGI
  • enlarged inguinal lymph nodes / MGI
  • enlarged popliteal lymph nodes / MGI
  • abnormal nipple development / MGI
  • abnormal skin appearance / MGI
  • abnormal Meibomian gland acinus morphology / MGI
  • abnormal vibrissa follicle morphology / MGI
  • abnormal skin adnexa physiology / MGI
  • abnormal hair follicle infundibulum morphology / MGI
  • dilated hair follicle infundibulum / MGI
  • abnormal hair follicle outer root sheath morphology / MGI
  • abnormal hair follicle inner root sheath morphology / MGI
  • absent hair follicle dermal papilla / MGI
  • dilated hair follicles / MGI
  • integument phenotype / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • lymph node medullary cord hyperplasia / MGI
  • small sebaceous gland / MGI
  • decreased sebocyte cell number / MGI
  • Meibomian gland cyst / MGI
  • decreased nipple number / MGI
  • thymus cortex atrophy / MGI
  • abnormal eyelid margin morphology / MGI
  • decreased small intestinal villus height / MGI
  • abnormal forehead morphology / MGI
  • abnormal piliary canal morphology / MGI
  • dilated piliary canal / MGI

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