- abnormal trabecular bone morphology / MGI
- abnormal cartilage morphology / MGI
- abnormal leukocyte cell number / MGI
- enlarged heart / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal coat/ hair morphology / MGI
- folliculitis / MGI
- abnormal hair follicle morphology / MGI
- underdeveloped hair follicles / MGI
- abnormal hair follicle orientation / MGI
- alopecia / MGI
- sparse hair / MGI
- short hair / MGI
- delayed hair appearance / MGI
- abnormal hair cycle / MGI
- amyloidosis / MGI
- enlarged sebaceous gland / MGI
- abnormal thyroid gland morphology / MGI
- enlarged lymph nodes / MGI
- abnormal thymus morphology / MGI
- abnormal spermatogenesis / MGI
- scaly skin / MGI
- dermatitis / MGI
- shiny skin / MGI
- thick skin / MGI
- skin lesions / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- abnormal epidermis stratum basale morphology / MGI
- hyperkeratosis / MGI
- thick dermal layer / MGI
- decreased body size / MGI
- short vibrissae / MGI
- sparse vibrissae / MGI
- absent vibrissae / MGI
- corneal opacity / MGI
- excessive scratching / MGI
- abnormal coat appearance / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- hyperglycemia / MGI
- abnormal visceral yolk sac morphology / MGI
- postnatal growth retardation / MGI
- increased inflammatory response / MGI
- liver inflammation / MGI
- salivary gland inflammation / MGI
- acanthosis / MGI
- abnormal hair growth / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal lymph node morphology / MGI
- abnormal lymph node cortex morphology / MGI
- abnormal thymus lobule morphology / MGI
- granulomatous inflammation / MGI
- heart left ventricle hypertrophy / MGI
- increased heart rate / MGI
- abnormal immune system organ morphology / MGI
- dilated cardiomyopathy / MGI
- increased heart weight / MGI
- abnormal keratinocyte physiology / MGI
- thymus atrophy / MGI
- abnormal hair follicle development / MGI
- abnormal hair shaft morphology / MGI
- greasy coat / MGI
- lymph node inflammation / MGI
- insulitis / MGI
- abnormal heartbeat / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased testis weight / MGI
- increased regulatory T cell number / MGI
- decreased osteoclast cell number / MGI
- abnormal lysosome morphology / MGI
- decreased cardiac muscle contractility / MGI
- cachexia / MGI
- abnormal myocardium layer morphology / MGI
- renal/urinary system phenotype / MGI
- abnormal thyroid hormone level / MGI
- decreased thyroxine level / MGI
- decreased ventricle muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- abnormal external auditory canal morphology / MGI
- mitral valve regurgitation / MGI
- aortic valve regurgitation / MGI
- decreased long bone epiphyseal plate size / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- lymph node hyperplasia / MGI
- enlarged heart left atrium / MGI
- abnormal hair cycle catagen phase / MGI
- abnormal thymus corticomedullary boundary morphology / MGI
- increased keratinocyte proliferation / MGI
- hypergranulosis / MGI
- orthokeratosis / MGI
- rough coat / MGI
- focal dorsal hair loss / MGI
- abnormal T wave / MGI
- abnormal heart electrocardiography waveform feature / MGI
- atrioventricular block / MGI
- hair follicle outer root sheath hyperplasia / MGI
- integument phenotype / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal visceral endoderm morphology / MGI
- dilated lymph node medullary sinus / MGI
- abnormal R wave / MGI
- abnormal heart echocardiography feature / MGI
- dental pulp necrosis / MGI
- enlarged thymus cortex / MGI
- periodontal ligament necrosis / MGI
- dilated piliary canal / MGI
C57BL/6NTac-Ctslem2(IMPC)H/H
| Status | Only small colony available |
| EMMA ID | EM:16508 |
| Citation information | RRID:IMSR_EM:16508 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Ctslem2(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ctslem2(IMPC)H |
| Gene/Transgene symbol | Ctsl |
Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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