C57BL/6NTac-Ctslem2(IMPC)H/H

Status

Only small colony available

EMMA IDEM:16508
Citation informationRRID:IMSR_EM:16508 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameC57BL/6NTac-Ctslem2(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCtslem2(IMPC)H
Gene/Transgene symbolCtsl

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal leukocyte cell number / MGI
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • abnormal coat/ hair morphology / MGI
  • folliculitis / MGI
  • abnormal hair follicle morphology / MGI
  • underdeveloped hair follicles / MGI
  • abnormal hair follicle orientation / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • short hair / MGI
  • delayed hair appearance / MGI
  • abnormal hair cycle / MGI
  • amyloidosis / MGI
  • enlarged sebaceous gland / MGI
  • abnormal thyroid gland morphology / MGI
  • enlarged lymph nodes / MGI
  • abnormal thymus morphology / MGI
  • abnormal spermatogenesis / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • shiny skin / MGI
  • thick skin / MGI
  • skin lesions / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • hyperkeratosis / MGI
  • thick dermal layer / MGI
  • decreased body size / MGI
  • short vibrissae / MGI
  • sparse vibrissae / MGI
  • absent vibrissae / MGI
  • corneal opacity / MGI
  • excessive scratching / MGI
  • abnormal coat appearance / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal cardiovascular system physiology / MGI
  • hyperglycemia / MGI
  • abnormal visceral yolk sac morphology / MGI
  • postnatal growth retardation / MGI
  • increased inflammatory response / MGI
  • liver inflammation / MGI
  • salivary gland inflammation / MGI
  • acanthosis / MGI
  • abnormal hair growth / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal lymph node morphology / MGI
  • abnormal lymph node cortex morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • granulomatous inflammation / MGI
  • heart left ventricle hypertrophy / MGI
  • increased heart rate / MGI
  • abnormal immune system organ morphology / MGI
  • dilated cardiomyopathy / MGI
  • increased heart weight / MGI
  • abnormal keratinocyte physiology / MGI
  • thymus atrophy / MGI
  • abnormal hair follicle development / MGI
  • abnormal hair shaft morphology / MGI
  • greasy coat / MGI
  • lymph node inflammation / MGI
  • insulitis / MGI
  • abnormal heartbeat / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased testis weight / MGI
  • increased regulatory T cell number / MGI
  • decreased osteoclast cell number / MGI
  • abnormal lysosome morphology / MGI
  • decreased cardiac muscle contractility / MGI
  • cachexia / MGI
  • abnormal myocardium layer morphology / MGI
  • renal/urinary system phenotype / MGI
  • abnormal thyroid hormone level / MGI
  • decreased thyroxine level / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • abnormal external auditory canal morphology / MGI
  • mitral valve regurgitation / MGI
  • aortic valve regurgitation / MGI
  • decreased long bone epiphyseal plate size / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • lymph node hyperplasia / MGI
  • enlarged heart left atrium / MGI
  • abnormal hair cycle catagen phase / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • increased keratinocyte proliferation / MGI
  • hypergranulosis / MGI
  • orthokeratosis / MGI
  • rough coat / MGI
  • focal dorsal hair loss / MGI
  • abnormal T wave / MGI
  • abnormal heart electrocardiography waveform feature / MGI
  • atrioventricular block / MGI
  • hair follicle outer root sheath hyperplasia / MGI
  • integument phenotype / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • dilated lymph node medullary sinus / MGI
  • abnormal R wave / MGI
  • abnormal heart echocardiography feature / MGI
  • dental pulp necrosis / MGI
  • enlarged thymus cortex / MGI
  • periodontal ligament necrosis / MGI
  • dilated piliary canal / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).