B6Brd;B6N-Tyrc-Brd Gmnntm1a(KOMP)Wtsi/WtsiH

Status

Only small colony available

EMMA IDEM:16557
Citation informationRRID:IMSR_EM:16557 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6Brd;B6N-Tyrc-Brd Gmnntm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0033_2_D07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGmnntm1a(KOMP)Wtsi
Gene/Transgene symbolGmnn
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0033_2_D07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal lens morphology / IMPC
  • cataract / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • abnormal lens morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • cataract / IMPC
MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • embryonic growth arrest / MGI
  • no abnormal phenotype detected / MGI
  • abnormal inner cell mass morphology / MGI
  • abnormal cell nucleus morphology / MGI
  • abnormal cell adhesion / MGI
  • abnormal mitosis / MGI
  • absent inner cell mass / MGI
  • abnormal trophectoderm morphology / MGI
  • abnormal cell differentiation / MGI
  • abnormal preimplantation embryo development / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • absent trophectoderm / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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