B6Brd;B6N-Tyr^c-Brd Miga2^{tm1a(KOMP)Wtsi}/WtsiH

Status	Only small colony available
EMMA ID	EM:16564
Citation information	RRID:IMSR_EM:16564 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Brd;B6N-Tyr^c-Brd Miga2^{tm1a(KOMP)Wtsi}/WtsiH
Alternative name	EPD0026_1_C12
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Miga2^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Miga2
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0026_1_C12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased bone mineral density / IMPC
decreased hematocrit / IMPC
abnormal cranium morphology / IMPC
abnormal snout morphology / IMPC
abnormal maxilla morphology / IMPC
decreased body length / IMPC
decreased body weight / IMPC
abnormal tooth morphology / IMPC
decreased hemoglobin content / IMPC
decreased erythrocyte cell number / IMPC
decreased lean body mass / IMPC
decreased total body fat amount / IMPC
decreased bone mineral content / IMPC
hypoplasia / IMPC
process of degenerative change / IMPC
glomerulonephritis / IMPC
lipid deposition / IMPC
osteopenia / IMPC
steatosis / IMPC

IMPC phenotypes (gene matching)

decreased body weight / IMPC
decreased lean body mass / IMPC
process of degenerative change / IMPC
hypoplasia / IMPC
decreased erythrocyte cell number / IMPC
decreased hematocrit / IMPC
decreased bone mineral content / IMPC
lipid deposition / IMPC
decreased total body fat amount / IMPC
osteopenia / IMPC
abnormal cranium morphology / IMPC
abnormal tooth morphology / IMPC
steatosis / IMPC
glomerulonephritis / IMPC
abnormal snout morphology / IMPC
abnormal maxilla morphology / IMPC
decreased bone mineral density / IMPC
decreased hemoglobin content / IMPC
decreased body length / IMPC

MGI phenotypes (gene matching)

decreased bone mineral density / MGI
decreased circulating LDL cholesterol level / MGI
decreased circulating HDL cholesterol level / MGI
decreased hematocrit / MGI
abnormal cranium morphology / MGI
abnormal snout morphology / MGI
abnormal maxilla morphology / MGI
decreased body length / MGI
decreased body weight / MGI
hyperactivity / MGI
abnormal tooth morphology / MGI
decreased hemoglobin content / MGI
decreased lean body mass / MGI
abnormal behavior / MGI
decreased circulating cholesterol level / MGI
decreased circulating serum albumin level / MGI
decreased circulating total protein level / MGI
decreased lactate dehydrogenase level / MGI
decreased circulating aspartate transaminase level / MGI
decreased total body fat amount / MGI
decreased bone mineral content / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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B6Brd;B6N-Tyrc-Brd Miga2tm1a(KOMP)Wtsi/WtsiH