C57BL/6NCrl-Dclre1cem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:16630
Citation informationRRID:IMSR_EM:16630 

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International strain nameC57BL/6NCrl-Dclre1cem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolDclre1cem1(IMPC)Ccpcz
Gene/Transgene symbolDclre1c

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • decreased thymocyte number / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • arrested T cell differentiation / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • abnormal B cell differentiation / MGI
  • small lymph nodes / MGI
  • abnormal lymph node morphology / MGI
  • abnormal leukocyte physiology / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • induced chromosome breakage / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • decreased thymus weight / MGI
  • decreased B-1 B cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • abnormal cell physiology / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • decreased NK T cell number / MGI
  • increased NK cell number / MGI
  • absent T cells / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • increased pro-B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent immature B cells / MGI
  • abnormal mononuclear cell morphology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal T cell receptor beta chain V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • chromosomal instability / MGI
  • decreased splenocyte number / MGI
  • decreased DN1 thymic pro-T cell number / MGI
  • decreased DN4 thymocyte number / MGI
  • absent thymus cortex / MGI
  • increased central memory CD4-positive, alpha-beta T cell number / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased central memory CD8 positive, alpha-beta T cell number / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI
  • decreased response to antigen / MGI
  • impaired humoral immune response / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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