- delayed bone ossification / MGI
- decreased bone mineral density / MGI
- osteoporosis / MGI
- abnormal frontal bone morphology / MGI
- cleft palate / MGI
- abnormal tooth development / MGI
- abnormal tooth eruption / MGI
- growth retardation of molars / MGI
- abnormal vertebrae morphology / MGI
- absent vertebrae / MGI
- rib fusion / MGI
- increased circulating LDL cholesterol level / MGI
- sparse hair / MGI
- abnormal head morphology / MGI
- abnormal head movements / MGI
- abnormal cranium morphology / MGI
- short limbs / MGI
- abnormal forelimb morphology / MGI
- abnormal hindlimb morphology / MGI
- polydactyly / MGI
- oligodactyly / MGI
- kinked tail / MGI
- short tail / MGI
- abnormal liver morphology / MGI
- enlarged liver / MGI
- abnormal liver physiology / MGI
- abnormal forebrain morphology / MGI
- forebrain hypoplasia / MGI
- abnormal telencephalon morphology / MGI
- abnormal cerebellum morphology / MGI
- abnormal midbrain morphology / MGI
- exencephaly / MGI
- fused dorsal root ganglion / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal eye development / MGI
- anophthalmia / MGI
- microphthalmia / MGI
- abnormal coat appearance / MGI
- hyperlipidemia / MGI
- increased circulating triglyceride level / MGI
- absent apical ectodermal ridge / MGI
- abnormal somite development / MGI
- incomplete somite formation / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- liver inflammation / MGI
- prenatal lethality / MGI
- abnormal limb morphology / MGI
- abnormal digit morphology / MGI
- abnormal lipid homeostasis / MGI
- no abnormal phenotype detected / MGI
- abnormal outer ear morphology / MGI
- abnormal nose morphology / MGI
- hepatic steatosis / MGI
- abnormal caudal vertebrae morphology / MGI
- abnormal tail bud morphology / MGI
- increased insulin sensitivity / MGI
- abnormal brown adipose tissue morphology / MGI
- no phenotypic analysis / MGI
- abnormal lumbar vertebrae morphology / MGI
- abnormal sacral vertebrae morphology / MGI
- curly tail / MGI
- spina bifida / MGI
- abnormal external female genitalia morphology / MGI
- abnormal forebrain development / MGI
- liver fibrosis / MGI
- sirenomelia / MGI
- abnormal neural tube closure / MGI
- increased circulating VLDL triglyceride level / MGI
- increased cholesterol level / MGI
- abnormal orientation of outer hair cell stereociliary bundles / MGI
- abnormal vertebral arch morphology / MGI
- vertebral fusion / MGI
- caudal vertebral fusion / MGI
- small caudal vertebrae / MGI
- short incisors / MGI
- increased adiponectin level / MGI
- cleft upper lip / MGI
- abnormal dorsal-ventral polarity of the somites / MGI
- abnormal vertebrae development / MGI
- abnormal fatty acid level / MGI
- improved glucose tolerance / MGI
- spina bifida occulta / MGI
- insulin resistance / MGI
- increased circulating aspartate transaminase level / MGI
- increased circulating bilirubin level / MGI
- small cranium / MGI
- decreased circulating glucose level / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased molar number / MGI
- small molars / MGI
- abnormal paraxial mesoderm morphology / MGI
- craniorachischisis / MGI
- hemivertebra / MGI
- absent inferior colliculus / MGI
- increased brown fat cell number / MGI
- abnormal external male genitalia morphology / MGI
- failure of eyelid fusion / MGI
- increased liver triglyceride level / MGI
- decreased liver triglyceride level / MGI
- decreased birth body size / MGI
- protruding tongue / MGI
- increased liver cholesterol level / MGI
- retina coloboma / MGI
- delayed cranial suture closure / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- abnormal head shape / MGI
- decreased somite size / MGI
- small tail bud / MGI
- abnormal tail ring morphology / MGI
- abnormal midbrain-hindbrain boundary morphology / MGI
- absent paraxial mesoderm / MGI
- spina bifida cystica / MGI
- decreased susceptibility to induced hypothermia / MGI
- small lower incisors / MGI
- long upper incisors / MGI
- thin neurocranium / MGI
- abnormal molar cusp morphology / MGI
C57BL/6NCrl-Lrp6em1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:16634 |
| Citation information | RRID:IMSR_EM:16634 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Lrp6em1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Lrp6em1(IMPC)Ccpcz |
| Gene/Transgene symbol | Lrp6 |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Oligodontia / Orphanet_99798
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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