- cleft palate / MGI
- absent tooth placode / MGI
- kyphosis / MGI
- decreased cell proliferation / MGI
- absent hair follicles / MGI
- decreased hair follicle number / MGI
- alopecia / MGI
- abnormal craniofacial morphology / MGI
- abnormal esophageal epithelium morphology / MGI
- abnormal esophageal squamous epithelium morphology / MGI
- abnormal stomach epithelium morphology / MGI
- abnormal stomach non-glandular epithelium morphology / MGI
- abnormal rectum morphology / MGI
- rectal prolapse / MGI
- distended urinary bladder / MGI
- abnormal urinary bladder urothelium morphology / MGI
- absent urinary bladder urothelium / MGI
- thin urinary bladder urothelium / MGI
- absent limbs / MGI
- abnormal forelimb morphology / MGI
- absent radius / MGI
- absent carpal bone / MGI
- absent hindlimb / MGI
- adactyly / MGI
- absent salivary gland / MGI
- absent mammary gland / MGI
- absent sebaceous gland / MGI
- enlarged lymph nodes / MGI
- weakness / MGI
- abnormal tongue epithelium morphology / MGI
- absent tongue squamous epithelium / MGI
- abnormal female reproductive system morphology / MGI
- abnormal uterine cervix epithelium morphology / MGI
- abnormal vagina epithelium morphology / MGI
- absent prostate gland / MGI
- abnormal skin condition / MGI
- shiny skin / MGI
- translucent skin / MGI
- blistering / MGI
- spontaneous skin ulceration / MGI
- wrinkled skin / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- absent epidermis / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum spinosum morphology / MGI
- absent epidermis stratum corneum / MGI
- distended abdomen / MGI
- absent vibrissae / MGI
- absent eyelids / MGI
- absent lacrimal glands / MGI
- circling / MGI
- dehydration / MGI
- abnormal embryo development / MGI
- abnormal ectoderm development / MGI
- abnormal apical ectodermal ridge morphology / MGI
- absent apical ectodermal ridge / MGI
- impaired wound healing / MGI
- kidney inflammation / MGI
- acanthosis / MGI
- hemorrhage / MGI
- neoplasm / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased lung adenoma incidence / MGI
- abnormal skin morphology / MGI
- premature death / MGI
- abnormal limb morphology / MGI
- abnormal limb bone morphology / MGI
- abnormal reproductive system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal tracheal ciliated epithelium morphology / MGI
- increased susceptibility to infection / MGI
- small uterus / MGI
- abnormal keratinocyte morphology / MGI
- abnormal keratinocyte differentiation / MGI
- impaired skin barrier function / MGI
- no phenotypic analysis / MGI
- abnormal septation of the cloaca / MGI
- abnormal esophagus development / MGI
- abnormal abdominal wall morphology / MGI
- rectovaginal fistula / MGI
- abnormal ventral body wall morphology / MGI
- abnormal keratinocyte physiology / MGI
- absent oviduct / MGI
- absent ovary / MGI
- kidney cysts / MGI
- abnormal hair follicle development / MGI
- abnormal facial morphology / MGI
- premature aging / MGI
- abnormal hair shaft morphology / MGI
- abnormal craniofacial development / MGI
- abnormal skin development / MGI
- aneuploidy / MGI
- decreased fetal size / MGI
- increased squamous cell carcinoma incidence / MGI
- decreased cellular sensitivity to ionizing radiation / MGI
- absent ulna / MGI
- abnormal pelvic girdle bone morphology / MGI
- small maxilla / MGI
- small limb buds / MGI
- small mandible / MGI
- intervertebral disk degeneration / MGI
- abnormal anus morphology / MGI
- gastric metaplasia / MGI
- ectrodactyly / MGI
- abnormal humerus morphology / MGI
- abnormal phalanx morphology / MGI
- muscle phenotype / MGI
- embryo phenotype / MGI
- reproductive system phenotype / MGI
- esophagogastric junction metaplasia / MGI
- abnormal skin physiology / MGI
- abnormal limb bud morphology / MGI
- abnormal corneal epithelium morphology / MGI
- abnormal mitochondrial physiology / MGI
- increased apoptosis / MGI
- decreased apoptosis / MGI
- abnormal limb development / MGI
- abnormal cellular replicative senescence / MGI
- early cellular replicative senescence / MGI
- abnormal olfactory epithelium morphology / MGI
- chromosomal instability / MGI
- clitoris hypoplasia / MGI
- uterine cervix inflammation / MGI
- increased histiocytic sarcoma incidence / MGI
- absent epidermis stratum granulosum / MGI
- decreased keratinocyte proliferation / MGI
- absent epidermis stratum spinosum / MGI
- abnormal secondary palate development / MGI
- abnormal prostate gland branching morphogenesis / MGI
- abnormal primitive urogenital sinus morphology / MGI
- umbilical hernia / MGI
- mortality/aging / MGI
- gastric cysts / MGI
- abnormal respiratory epithelium morphology / MGI
- neonatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- dermal-epidermal separation / MGI
- abnormal urinary bladder detrusor smooth muscle morphology / MGI
- small tail bud / MGI
- abnormal olfactory gland morphology / MGI
- abnormal horizontal basal cell of olfactory epithelium morphology / MGI
- urinary bladder exstrophy / MGI
- absent pubic symphysis / MGI
- absent teeth / MGI
C57BL/6NCrl-Trp63em1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:16636 |
| Citation information | RRID:IMSR_EM:16636 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Trp63em1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Trp63em1(IMPC)Ccpcz |
| Gene/Transgene symbol | Trp63 |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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