- absent mandible / MGI
- decreased hematocrit / MGI
- increased cell proliferation / MGI
- abnormal digestive system morphology / MGI
- gastrointestinal hemorrhage / MGI
- abnormal foregut morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- rectal prolapse / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal mammary gland development / MGI
- mammary gland hyperplasia / MGI
- abnormal brain development / MGI
- abnormal floor plate morphology / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina epithelium morphology / MGI
- dermal cysts / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased metastatic potential / MGI
- abnormal nursing / MGI
- hunched posture / MGI
- hyperlipidemia / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- anemia / MGI
- extended life span / MGI
- abnormal embryo development / MGI
- abnormal embryo size / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- postnatal growth retardation / MGI
- increased mammary adenocarcinoma incidence / MGI
- neoplasm / MGI
- increased pilomatricoma incidence / MGI
- increased tumor incidence / MGI
- increased incidence of induced tumors / MGI
- increased colon adenoma incidence / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- increased intestinal adenoma incidence / MGI
- hepatic steatosis / MGI
- increased trichoepithelioma incidence / MGI
- increased intestinal adenocarcinoma incidence / MGI
- no phenotypic analysis / MGI
- abnormal egg cylinder morphology / MGI
- acrania / MGI
- colon polyps / MGI
- intestinal obstruction / MGI
- melena / MGI
- rectal hemorrhage / MGI
- gastric polyps / MGI
- increased hepatocellular carcinoma incidence / MGI
- epidermal cyst / MGI
- decreased tumor growth/size / MGI
- abnormal tumor morphology / MGI
- abnormal intestinal goblet cell morphology / MGI
- increased tumor growth/size / MGI
- increased osteosarcoma incidence / MGI
- decreased macrophage cell number / MGI
- abnormal embryonic epiblast morphology / MGI
- aneuploidy / MGI
- abnormal primitive node morphology / MGI
- cardia bifida / MGI
- increased incidence of tumors by chemical induction / MGI
- split notochord / MGI
- ovary atrophy / MGI
- abnormal large intestine crypts of Lieberkuhn morphology / MGI
- uterus atrophy / MGI
- decreased T cell number / MGI
- increased circulating cholesterol level / MGI
- cellular phenotype / MGI
- reproductive system phenotype / MGI
- abnormal cell physiology / MGI
- increased apoptosis / MGI
- abnormal hindbrain development / MGI
- absent male preputial gland / MGI
- intestine polyps / MGI
- increased liver tumor incidence / MGI
- decreased NK cell number / MGI
- abnormal anterior visceral endoderm morphology / MGI
- embryonic lethality / MGI
- abnormal enterocyte proliferation / MGI
- adrenal gland hyperplasia / MGI
- abnormal mesendoderm development / MGI
- increased small intestine adenocarcinoma incidence / MGI
- increased large intestine adenocarcinoma incidence / MGI
- decreased splenocyte number / MGI
- abnormal pregnancy / MGI
- absent nipple / MGI
- increased prostaglandin level / MGI
- embryonic lethality between implantation and placentation / MGI
- increased gastrointestinal tumor incidence / MGI
- increased mammary gland tumor incidence / MGI
- increased skin tumor incidence / MGI
- increased stomach tumor incidence / MGI
- increased osteoma incidence / MGI
- increased desmoid tumor incidence / MGI
- gastrointestinal tract polyps / MGI
- increased adenoma incidence / MGI
- altered tumor pathology / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- absent midbrain / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral-caudal axis duplication / MGI
- rostral body truncation / MGI
- absent neural folds / MGI
- abnormal head development / MGI
- decreased intestinal adenoma incidence / MGI
- abnormal endocardial heart tube morphology / MGI
C57BL/6NCrl-Apcem1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:16663 |
| Citation information | RRID:IMSR_EM:16663 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Apcem1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Apcem1(IMPC)Ccpcz |
| Gene/Transgene symbol | Apc |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Desmoid tumor / Orphanet_873
- Cenani-Lenz syndrome / Orphanet_3258
- Turcot syndrome with polyposis / Orphanet_99818
- Gastric adenocarcinoma and proximal polyposis of the stomach / Orphanet_314022
- Gardner syndrome / Orphanet_79665
- APC-related attenuated familial adenomatous polyposis / Orphanet_247806
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).
