C57BL/6NCrl-Dlx5em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:16673
Citation informationRRID:IMSR_EM:16673 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameC57BL/6NCrl-Dlx5em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolDlx5em1(IMPC)Ccpcz
Gene/Transgene symbolDlx5

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • absent semicircular canals / MGI
  • abnormal otic capsule morphology / MGI
  • absent endolymphatic duct / MGI
  • abnormal middle ear morphology / MGI
  • delayed bone ossification / MGI
  • abnormal neurocranium morphology / MGI
  • abnormal interparietal bone morphology / MGI
  • abnormal basioccipital bone morphology / MGI
  • large anterior fontanelle / MGI
  • short mandible / MGI
  • short premaxilla / MGI
  • short maxilla / MGI
  • abnormal vomer bone morphology / MGI
  • abnormal nasal bone morphology / MGI
  • abnormal basisphenoid bone morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal rib morphology / MGI
  • abnormal cell proliferation / MGI
  • absent palatine bone horizontal plate / MGI
  • abnormal cranium morphology / MGI
  • abnormal snout morphology / MGI
  • short snout / MGI
  • abnormal mouth morphology / MGI
  • abnormal jaw morphology / MGI
  • abnormal maxilla morphology / MGI
  • abnormal mandible morphology / MGI
  • abnormal hindlimb morphology / MGI
  • syndactyly / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • small trigeminal ganglion / MGI
  • decreased body size / MGI
  • distended abdomen / MGI
  • hypoactivity / MGI
  • abnormal suckling behavior / MGI
  • anencephaly / MGI
  • respiratory distress / MGI
  • perinatal lethality / MGI
  • abnormal vibrissa morphology / MGI
  • abnormal digit morphology / MGI
  • abnormal craniofacial bone morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal outer ear morphology / MGI
  • abnormal nasal mucosa morphology / MGI
  • abnormal larynx morphology / MGI
  • abnormal thyroid cartilage morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • brachydactyly / MGI
  • abnormal sexual interaction / MGI
  • micrognathia / MGI
  • abnormal molar morphology / MGI
  • small olfactory bulb / MGI
  • abnormal tooth mineralization / MGI
  • abnormal premaxilla morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • abnormal metatarsal bone morphology / MGI
  • decreased cochlear coiling / MGI
  • decreased lateral semicircular canal size / MGI
  • absent posterior semicircular canal / MGI
  • absent superior semicircular canal / MGI
  • abnormal scala vestibuli morphology / MGI
  • abnormal alisphenoid bone morphology / MGI
  • abnormal GABAergic neuron morphology / MGI
  • abnormal axon extension / MGI
  • abnormal palate morphology / MGI
  • ectopic cartilage / MGI
  • abnormal molar crown morphology / MGI
  • abnormal craniofacial development / MGI
  • abnormal tongue muscle morphology / MGI
  • absent stapes / MGI
  • abnormal pterygoid muscle morphology / MGI
  • abnormal crista ampullaris morphology / MGI
  • abnormal rostral migratory stream morphology / MGI
  • otic vesicle hypoplasia / MGI
  • abnormal vestibular saccular macula morphology / MGI
  • abnormal utricular macula morphology / MGI
  • enlarged utricle / MGI
  • small interparietal bone / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • small parietal bone / MGI
  • abnormal temporal bone squamous part morphology / MGI
  • absent Meckel's cartilage / MGI
  • small supraoccipital bone / MGI
  • abnormal pterygoid process morphology / MGI
  • abnormal pterygoid bone morphology / MGI
  • small nasal bone / MGI
  • short nasal bone / MGI
  • turbinate hypoplasia / MGI
  • small maxilla / MGI
  • abnormal mandibular coronoid process morphology / MGI
  • abnormal mandibular condyloid process morphology / MGI
  • abnormal mandibular angle morphology / MGI
  • abnormal stapedial artery morphology / MGI
  • abnormal nasal capsule morphology / MGI
  • absent mandibular coronoid process / MGI
  • abnormal middle ear ossicle morphology / MGI
  • ectrodactyly / MGI
  • abnormal olfactory nerve morphology / MGI
  • abnormal occipital bone morphology / MGI
  • abnormal zygomatic bone morphology / MGI
  • abnormal lacrimal bone morphology / MGI
  • abnormal viscerocranium morphology / MGI
  • abnormal phalanx morphology / MGI
  • abnormal incisor morphology / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • decreased tympanic ring size / MGI
  • abnormal external auditory canal morphology / MGI
  • abnormal vestibular saccule morphology / MGI
  • otic capsule hypoplasia / MGI
  • abnormal nasal pit morphology / MGI
  • abnormal first pharyngeal arch morphology / MGI
  • abnormal styloid process morphology / MGI
  • short endolymphatic duct / MGI
  • abnormal bone ossification / MGI
  • small malleus processus brevis / MGI
  • abnormal gonial bone morphology / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal olfactory epithelium morphology / MGI
  • meteorism / MGI
  • absent gastric milk in neonates / MGI
  • cleft secondary palate / MGI
  • cleft primary palate / MGI
  • decreased maxillary shelf size / MGI
  • abnormal frontonasal prominence morphology / MGI
  • abnormal lateral nasal prominence morphology / MGI
  • abnormal hyoid bone greater horn morphology / MGI
  • abnormal hyoid bone lesser horn morphology / MGI
  • abnormal stylohyoid ligament morphology / MGI
  • abnormal olfactory bulb granule cell morphology / MGI
  • abnormal olfactory bulb periglomerular cell morphology / MGI
  • abnormal mitral cell morphology / MGI
  • abnormal basicranium morphology / MGI
  • delayed cranial suture closure / MGI
  • abnormal mandibular prominence morphology / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal head development / MGI
  • absent vomeronasal organ / MGI
  • small vomeronasal organ / MGI
  • short Meckel's cartilage / MGI
  • absent olfactory epithelium / MGI
  • ectopic cranial bone / MGI
  • decreased bone mineralization / MGI
  • fused pharyngeal arches / MGI
  • wide cranial sutures / MGI
  • Wormian bones / MGI
  • small lacrimal bone / MGI
  • short lower incisors / MGI
  • short upper incisors / MGI
  • abnormal mylohyoid muscle morphology / MGI
  • abnormal epitympanic recess morphology / MGI
  • deviated nasal septum / MGI
  • short nasal septum / MGI
  • abnormal intrinsic tongue muscle morphology / MGI
  • frontonasal prominence hypoplasia / MGI
  • small vomer bone / MGI
  • lower jaw to upper jaw transformation / MGI
  • abnormal tegmen tympani morphology / MGI
  • short styloid process / MGI
  • small presphenoid bone / MGI
  • abnormal outer ear cartilage morphology / MGI
  • abnormal superior horn of thyroid cartilage morphology / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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