C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/Ics

Status

Under development - register interest

EMMA IDEM:16696
Citation informationRRID:IMSR_EM:16696 

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International strain nameC57BL/6N-Coq6tm1b(EUCOMM)Hmgu/Ics
Alternative nameHEPD0535_5_A07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCoq6tm1b(EUCOMM)Hmgu
Gene/Transgene symbolCoq6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0535_5_A07. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics). Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Familial steroid-resistant nephrotic syndrome with sensorineural deafness / Orphanet_280406
IMPC phenotypes (allele matching)
  • persistence of hyaloid vascular system / IMPC
  • abnormal cornea morphology / IMPC
  • abnormal embryo size / IMPC
  • abnormal vitreous body morphology / IMPC
  • abnormal tail bud morphology / IMPC
  • abnormal forebrain development / IMPC
  • embryonic growth retardation / IMPC
  • increased circulating sodium level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased fasting circulating glucose level / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
IMPC phenotypes (gene matching)
  • embryonic growth retardation / IMPC
  • abnormal embryo size / IMPC
  • abnormal vitreous body morphology / IMPC
  • abnormal forebrain development / IMPC
  • persistence of hyaloid vascular system / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal cornea morphology / IMPC
  • abnormal tail bud morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased circulating sodium level / IMPC
  • increased fasting circulating glucose level / IMPC

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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