C57BL/6N-Tmprss6tm1b(EUCOMM)Wtsi/Ics

Status

Under development - register interest

EMMA IDEM:16702
Citation informationRRID:IMSR_EM:16702 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Tmprss6tm1b(EUCOMM)Wtsi/Ics
Alternative nameEPD0453_1_B07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTmprss6tm1b(EUCOMM)Wtsi
Gene/Transgene symbolTmprss6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0453_1_B07. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics). Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased circulating calcium level / IMPC
  • decreased hematocrit / IMPC
  • abnormal coat/ hair morphology / IMPC
  • decreased locomotor activity / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal coat appearance / IMPC
  • abnormal skin morphology / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased mean corpuscular volume / IMPC
  • short tibia / IMPC
  • increased heart weight / IMPC
  • decreased hemoglobin content / IMPC
  • immune system phenotype / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • decreased NK cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased prepulse inhibition / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased fasting circulating glucose level / IMPC
  • increased CD11b-high dendritic cell number / IMPC
  • increased Ly6C-positive mature NK cell number / IMPC
IMPC phenotypes (gene matching)
  • short tibia / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • abnormal coat/ hair morphology / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal skin morphology / IMPC
  • decreased locomotor activity / IMPC
  • increased heart weight / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal coat appearance / IMPC
  • increased Ly6C-positive mature NK cell number / IMPC
  • decreased NK cell number / IMPC
  • increased circulating calcium level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased CD11b-high dendritic cell number / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased hemoglobin content / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • immune system phenotype / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased hematocrit / IMPC

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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