B6Brd;B6N-Tyr^c-Brd Slc25a21^{tm1a(KOMP)Wtsi}/WtsiCnrm

Status	Under development - register interest
EMMA ID	EM:16720
Citation information	RRID:IMSR_EM:16720 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Brd;B6N-Tyr^c-Brd Slc25a21^{tm1a(KOMP)Wtsi}/WtsiCnrm
Alternative name	EPD0085_1_D04
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Slc25a21^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Slc25a21
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0085_1_D04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased bone mineral density / IMPC
abnormal cranium morphology / IMPC
abnormal snout morphology / IMPC
abnormal mandible morphology / IMPC
decreased body length / IMPC
decreased body weight / IMPC
abnormal tooth morphology / IMPC
abnormal joint morphology / IMPC
decreased lean body mass / IMPC
vertebral fusion / IMPC
abnormal incisor morphology / IMPC
absent pinna reflex / IMPC
decreased total body fat amount / IMPC
decreased bone mineral content / IMPC

IMPC phenotypes (gene matching)

decreased circulating magnesium level / IMPC
decreased body weight / IMPC
abnormal mandible morphology / IMPC
abnormal tooth morphology / IMPC
abnormal cranium morphology / IMPC
decreased lean body mass / IMPC
increased total body fat amount / IMPC
decreased body length / IMPC
abnormal snout morphology / IMPC
abnormal joint morphology / IMPC
decreased bone mineral density / IMPC
decreased bone mineral content / IMPC
vertebral fusion / IMPC
abnormal incisor morphology / IMPC
decreased mean corpuscular hemoglobin / IMPC
decreased total body fat amount / IMPC
absent pinna reflex / IMPC
decreased mean corpuscular volume / IMPC

MGI phenotypes (allele matching)

decreased circulating LDL cholesterol level / MGI
abnormal cranium morphology / MGI
abnormal snout morphology / MGI
abnormal mandible morphology / MGI
decreased body length / MGI
decreased body weight / MGI
abnormal tooth morphology / MGI
abnormal joint morphology / MGI
decreased circulating alanine transaminase level / MGI
abnormal incisor morphology / MGI
decreased circulating potassium level / MGI
decreased circulating aspartate transaminase level / MGI
absent pinna reflex / MGI
decreased total body fat amount / MGI
decreased bone mineral content / MGI

MGI phenotypes (gene matching)

decreased circulating LDL cholesterol level / MGI
abnormal cranium morphology / MGI
abnormal snout morphology / MGI
abnormal mandible morphology / MGI
decreased body length / MGI
decreased body weight / MGI
abnormal tooth morphology / MGI
abnormal joint morphology / MGI
decreased circulating alanine transaminase level / MGI
abnormal incisor morphology / MGI
decreased circulating potassium level / MGI
decreased circulating aspartate transaminase level / MGI
absent pinna reflex / MGI
decreased total body fat amount / MGI
decreased bone mineral content / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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B6Brd;B6N-Tyrc-Brd Slc25a21tm1a(KOMP)Wtsi/WtsiCnrm