C3HeB/FeJ-Ednram1Mhda/Ieg

Status

Available to order

EMMA IDEM:01675
International strain nameC3HeB/FeJ-Ednram1Mhda/Ieg
Alternative nameAEA001
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolEdnram1Mhda,
Gene/Transgene symbolEdnra

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationAbnormal ear
Phenotypic informationAbnormal ear
References
  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
  • Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017
  • Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.;Sabrautzki Sibylle, Sandholzer Michael A, Lorenz-Depiereux Bettina, Brommage Robert, Przemeck Gerhard, Vargas Panesso Ingrid L, Vernaleken Alexandra, Garrett Lillian, Baron Katharina, Yildirim Ali O, Rozman Jan, Rathkolb Birgit, Gau Christine, Hans Wolfgang, Hoelter Sabine M, Marschall Susan, Stoeger Claudia, Becker Lore, Fuchs Helmut, Gailus-Durner Valerie, Klingenspor Martin, Klopstock Thomas, Lengger Christoph, Stefanie Leuchtenberger, Wolf Eckhard, Strom Tim M, Wurst Wolfgang, de Angelis Martin Hrabě, ;2016;Mammalian genome : official journal of the International Mammalian Genome Society;27;587-598; 27671791

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal malleus morphology / MGI
  • short mandible / MGI
  • malocclusion / MGI
  • abnormal cranium morphology / MGI
  • decreased startle reflex / MGI
  • abnormal respiration / MGI
  • abnormal vital capacity / MGI
  • abnormal inspiratory capacity / MGI
  • micrognathia / MGI
  • abnormal zygomatic bone morphology / MGI
  • impaired hearing / MGI
  • decreased prepulse inhibition / MGI
  • integument phenotype / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal incudomalleolar joint morphology / MGI
  • abnormal temporal bone zygomatic process morphology / MGI
  • abnormal temporal bone petrous part morphology / MGI
  • absent incus short process / MGI
  • absent temporal bone zygomatic process / MGI
  • abnormal ear shape / MGI
  • lowered ear position / MGI
  • shortened head / MGI
  • short snout / MGI
  • abnormal jaw morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • macrophthalmia / MGI
  • abnormal zygomatic arch morphology / MGI
  • abnormal mandibular condyloid process morphology / MGI
  • conductive hearing loss / MGI
  • abnormal orbit morphology / MGI
  • decreased lung compliance / MGI
  • decreased total lung capacity / MGI
  • abnormal temporomandibular joint morphology / MGI
  • round face / MGI
  • abnormal outer ear helix morphology / MGI
  • round orbits / MGI
  • prominent cheeks / MGI
  • wide coronal suture / MGI
  • wide sagittal suture / MGI
  • wide lambdoid suture / MGI

Literature references

  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
  • Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017
  • Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.;Sabrautzki Sibylle, Sandholzer Michael A, Lorenz-Depiereux Bettina, Brommage Robert, Przemeck Gerhard, Vargas Panesso Ingrid L, Vernaleken Alexandra, Garrett Lillian, Baron Katharina, Yildirim Ali O, Rozman Jan, Rathkolb Birgit, Gau Christine, Hans Wolfgang, Hoelter Sabine M, Marschall Susan, Stoeger Claudia, Becker Lore, Fuchs Helmut, Gailus-Durner Valerie, Klingenspor Martin, Klopstock Thomas, Lengger Christoph, Stefanie Leuchtenberger, Wolf Eckhard, Strom Tim M, Wurst Wolfgang, de Angelis Martin Hrabě, ;2016;Mammalian genome : official journal of the International Mammalian Genome Society;27;587-598; 27671791

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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