C57Bl/6NTac-Aqp5^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:16754
Citation information	RRID:IMSR_EM:16754 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57Bl/6NTac-Aqp5^em1(IMPC)H/H
Alternative name	C57Bl/6NTac-Aqp5/H
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Aqp5^em1(IMPC)H
Gene/Transgene symbol	Aqp5

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This strain carries a CRISPR/Cas9 induced deletion of 606 nt from Aqp5 gene, across two critical exons (ENSMUSE00000297625 & ENSMUSE00001018343.) to introduce a frameshift resulting in a premature stop codon null allele in 3 of 4 transcripts.
Phenotypic information	Homozygous: These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at https://www.mousephenotype.org/data/genes/MGI:106215 Heterozygous: These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at https://www.mousephenotype.org/data/genes/MGI:106215
Breeding history	Coisogenic on maintained background
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Non-epidermolytic palmoplantar keratoderma / Orphanet_2337

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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C57Bl/6NTac-Aqp5em1(IMPC)H/H