C57BL/6NTac-Cdkn1bem1(IMPC)H/H

Status

Available to order

EMMA IDEM:16756
Citation informationRRID:IMSR_EM:16756 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Cdkn1bem1(IMPC)H/H
Alternative nameC57BL/6NTac-Cdkn1b/H
Strain typeEndonuclease-mediated
Allele/Transgene symbolCdkn1bem1(IMPC)H
Gene/Transgene symbolCdkn1b

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis is a CRISPR/Cas9 induced mutation deleting 10 nucleotides from the Cdkn1b gene, encompassing/within a critical exon to introduce a frameshift resulting in a premature stop codon/null allele. The stock was generated at MRC Harwell via microinjection of CRISPR/Cas9 reagents into 1-cell stage embryos.
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at https://www.mousephenotype.org/data/genes/MGI:104565

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at https://www.mousephenotype.org/data/genes/MGI:104565
Breeding historyCoisogenic on maintained background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased fasting circulating glucose level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased bone mineral content / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal retina morphology / IMPC
  • increased spleen weight / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal optic disk morphology / IMPC
  • decreased bone mineral density / IMPC
  • decreased mean corpuscular volume / IMPC
  • abnormal startle reflex / IMPC
  • decreased monocyte cell number / IMPC
MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • abnormal organ of Corti morphology / MGI
  • enlarged heart / MGI
  • heart hyperplasia / MGI
  • abnormal cell proliferation / MGI
  • decreased cell proliferation / MGI
  • abnormal hepatocyte morphology / MGI
  • pituitary gland hyperplasia / MGI
  • enlarged pituitary gland / MGI
  • enlarged adrenal glands / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • spleen hypoplasia / MGI
  • abnormal thymus morphology / MGI
  • thymus hyperplasia / MGI
  • enlarged thymus / MGI
  • increased thymocyte number / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal epithalamus morphology / MGI
  • abnormal retinal photoreceptor morphology / MGI
  • abnormal uterus morphology / MGI
  • abnormal ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent corpus luteum / MGI
  • enlarged testis / MGI
  • testicular hyperplasia / MGI
  • increased body weight / MGI
  • increased body size / MGI
  • disorganized retinal layers / MGI
  • female infertility / MGI
  • increased lung adenocarcinoma incidence / MGI
  • increased pituitary adenoma incidence / MGI
  • premature death / MGI
  • abnormal tooth morphology / MGI
  • abnormal definitive hematopoiesis / MGI
  • increased brain weight / MGI
  • abnormal corpus luteum morphology / MGI
  • decreased circulating testosterone level / MGI
  • increased heart weight / MGI
  • delayed wound healing / MGI
  • no phenotypic analysis / MGI
  • abnormal fetal cardiomyocyte proliferation / MGI
  • abnormal prostate gland physiology / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal pillar cell morphology / MGI
  • increased kidney weight / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • increased cochlear hair cell number / MGI
  • increased organ of Corti supporting cell number / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • small myocardial fiber / MGI
  • enlarged ovary / MGI
  • increased spleen weight / MGI
  • increased thymus weight / MGI
  • enlarged prostate gland / MGI
  • increased T cell number / MGI
  • decreased T cell proliferation / MGI
  • increased circulating cholesterol level / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • increased T cell proliferation / MGI
  • behavior/neurological phenotype / MGI
  • abnormal Muller cell morphology / MGI
  • abnormal eye electrophysiology / MGI
  • abnormal neuronal migration / MGI
  • abnormal retinal neuronal layer morphology / MGI
  • increased myocardial fiber number / MGI
  • impaired hearing / MGI
  • increased ovary tumor incidence / MGI
  • increased amacrine cell number / MGI
  • abnormal pituitary intermediate lobe morphology / MGI
  • adrenal medulla hyperplasia / MGI
  • pituitary intermediate lobe hyperplasia / MGI
  • abnormal granulosa cell morphology / MGI
  • increased pituitary gland weight / MGI
  • prolonged estrous cycle / MGI
  • prolonged estrus / MGI
  • endometrium hyperplasia / MGI
  • increased white fat cell number / MGI
  • increased inguinal fat pad weight / MGI
  • increased parametrial fat pad weight / MGI
  • abnormal secondary ovarian follicle morphology / MGI
  • abnormal prostate gland dorsolateral lobe morphology / MGI
  • decreased keratinocyte proliferation / MGI
  • abnormal neuron differentiation / MGI
  • abnormal retina outer limiting membrane morphology / MGI
  • increased pituitary gland tumor incidence / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).