IMPC phenotypes (gene matching)
- decreased circulating HDL cholesterol level / IMPC
C57BL/6N-Cyfip1tm2b(EUCOMM)Wtsi/H
| Status | Under development - register interest |
| EMMA ID | EM:16758 |
| Citation information | RRID:IMSR_EM:16758 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Cyfip1tm2b(EUCOMM)Wtsi/H |
| Alternative name | C57BL/6N-Cyfip1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cyfip1tm2b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Cyfip1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from ESC clone EPD0555_2_B11. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele . For further details on the construction of this clone see the page at the IMPC portal |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- open neural tube / MGI
- abnormal anxiety-related response / MGI
- hypoactivity / MGI
- abnormal long term depression / MGI
- abnormal CNS synaptic transmission / MGI
- enhanced paired-pulse facilitation / MGI
- kinked neural tube / MGI
- delayed somite formation / MGI
- abnormal rostral-caudal body axis extension / MGI
- enhanced cued conditioning behavior / MGI
- impaired somite development / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI