IMPC phenotypes (allele matching)
STOCK Micu1tm1bNarl/H
| Status | Under development - register interest |
| EMMA ID | EM:16762 |
| Citation information | RRID:IMSR_EM:16762 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Micu1tm1bNarl/H |
| Alternative name | STOCK Micu1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Micu1tm1bNarl |
| Gene/Transgene symbol | Micu1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | The L1L2_Bact_P cassette was inserted upstream of the critical exon 7. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 8. The critical exons 7 and 8 are thus flanked by loxP sites. Cre-mediated recombination without flp expression created a null reporter knockout mouse. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| Breeding history | The tm1a mice were imported on n undefined C57BL/6 background. The strain has since been converted to a tm1b and maintained on a C57BL/6NTac USA background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Proximal myopathy with extrapyramidal signs / Orphanet_401768