C57BL/6NTac-Aqp1tm1c(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:16764
Citation informationRRID:IMSR_EM:16764 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Aqp1tm1c(EUCOMM)Wtsi/H
Alternative nameC57BL/6NTac-Aqp1/H
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAqp1tm1c(EUCOMM)Wtsi
Gene/Transgene symbolAqp1

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from ESC clone EPD0140_5_D09, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased bone mineral density / IMPC
  • decreased locomotor activity / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased grip strength / IMPC
  • decreased circulating chloride level / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased bone mineral content / IMPC
  • increased neutrophil cell number / IMPC
  • increased lean body mass / IMPC
  • impaired glucose tolerance / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating amylase level / IMPC
  • decreased total body fat amount / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating creatinine level / IMPC
  • increased circulating total protein level / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • dehydration / MGI
  • postnatal growth retardation / MGI
  • abnormal respiratory system physiology / MGI
  • decreased urine osmolality / MGI
  • decreased vascular permeability / MGI
  • nervous system phenotype / MGI
  • abnormal myocardial fiber physiology / MGI
  • lethargy / MGI
  • hearing/vestibular/ear phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • behavior/neurological phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased urine sodium level / MGI
  • dilated rete testis / MGI
  • increased blood osmolality / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal renal water transport / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

Example health report
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