IMPC phenotypes (gene matching)
C57BL/6N-Slc40a1tm1c(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:16770 |
| Citation information | RRID:IMSR_EM:16770 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Slc40a1tm1c(EUCOMM)Hmgu/H |
| Alternative name | C57BL/6N-Slc40a1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc40a1tm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Slc40a1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone HEPD0551_2_A07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hemochromatosis type 4 / Orphanet_139491
MGI phenotypes (gene matching)
- abnormal liver morphology / MGI
- abnormal liver physiology / MGI
- small spleen / MGI
- microphthalmia / MGI
- anemia / MGI
- decreased embryo size / MGI
- edema / MGI
- abnormal pancreas morphology / MGI
- premature death / MGI
- abnormal erythrocyte morphology / MGI
- abnormal macrophage physiology / MGI
- increased mean corpuscular volume / MGI
- decreased mean corpuscular volume / MGI
- increased hematocrit / MGI
- anisocytosis / MGI
- polycythemia / MGI
- decreased hemoglobin content / MGI
- increased erythrocyte cell number / MGI
- abnormal forebrain development / MGI
- nervous system phenotype / MGI
- oxidative stress / MGI
- pallor / MGI
- abnormal neural tube closure / MGI
- decreased thermal nociceptive threshold / MGI
- decreased circulating iron level / MGI
- cachexia / MGI
- abnormal enzyme/coenzyme level / MGI
- homeostasis/metabolism phenotype / MGI
- vision/eye phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- abnormal iron homeostasis / MGI
- hemochromatosis / MGI
- hypochromic microcytic anemia / MGI
- abnormal spleen physiology / MGI
- decreased liver iron level / MGI
- increased liver iron level / MGI
- decreased spleen iron level / MGI
- increased spleen iron level / MGI
- increased circulating iron level / MGI
- abnormal pancreatic acinar cell morphology / MGI
- increased splenocyte apoptosis / MGI
- abnormal spleen development / MGI
- leptocytosis / MGI
- increased kidney iron level / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- increased circulating lipase level / MGI
- increased circulating ferritin level / MGI
- increased circulating unsaturated transferrin level / MGI
- decreased circulating unsaturated transferrin level / MGI
- increased pancreas iron level / MGI
- increased brain iron level / MGI
- increased heart iron level / MGI
- decreased intestinal iron level / MGI