C57BL/6N-Nptntm1c(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:16778
Citation informationRRID:IMSR_EM:16778 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Nptntm1c(EUCOMM)Hmgu/H
Alternative nameC57BL/6N-Nptn/H
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolNptn
Gene/Transgene symbolNptn

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from ESC clone HEPD0633_1_A06, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased prepulse inhibition / IMPC
  • abnormal gait / IMPC
  • abnormal behavior / IMPC
  • increased circulating iron level / IMPC
  • hyperactivity / IMPC
  • abnormal iris morphology / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased anxiety-related response / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating phosphate level / IMPC
  • limb grasping / IMPC
  • decreased thigmotaxis / IMPC
  • abnormal startle reflex / IMPC
  • decreased locomotor activity / IMPC
  • abnormal ear morphology / IMPC
  • increased mean corpuscular volume / IMPC
  • increased bone mineral content / IMPC
  • increased circulating cholesterol level / IMPC
  • tremors / IMPC
  • increased heart weight / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased hemoglobin content / IMPC
MGI phenotypes (gene matching)
  • trunk curl / MGI
  • impaired swimming / MGI
  • impaired righting response / MGI
  • abnormal CNS synaptic transmission / MGI
  • nervous system phenotype / MGI
  • decreased cochlear outer hair cell number / MGI
  • abnormal cochlear inner hair cell physiology / MGI
  • abnormal inner hair cell synaptic ribbon morphology / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • decreased CNS synapse formation / MGI
  • head tilt / MGI
  • impaired hearing / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • abnormal dendritic spine morphology / MGI
  • increased or absent threshold for auditory brainstem response / MGI

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Practical information

Genotyping protocol

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