IMPC phenotypes (gene matching)
C57BL/6N-Timp1tm1c(EUCOMM)Hmgu/H
| Status | Under development - register interest |
| EMMA ID | EM:16781 |
| Citation information | RRID:IMSR_EM:16781 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Timp1tm1c(EUCOMM)Hmgu/H |
| Alternative name | C57BL/6N-Timp1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Timp1tm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Timp1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone HEPD0680_9_H10, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased neutrophil cell number / MGI
- decreased bone marrow cell number / MGI
- altered response to myocardial infarction / MGI
- lung hemorrhage / MGI
- weight loss / MGI
- lung inflammation / MGI
- reduced female fertility / MGI
- decreased litter size / MGI
- neoplasm / MGI
- decreased susceptibility to bacterial infection / MGI
- increased vascular permeability / MGI
- abnormal uterus development / MGI
- increased left ventricle diastolic pressure / MGI
- increased uterus weight / MGI
- increased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- growth/size/body region phenotype / MGI
- respiratory system phenotype / MGI
- reproductive system phenotype / MGI
- hematopoietic system phenotype / MGI
- aortic aneurysm / MGI
- absent estrous cycle / MGI
- prolonged proestrus / MGI
- abnormal estrus / MGI
- short estrus / MGI
- absent estrus / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal endometrial gland development / MGI