IMPC phenotypes (gene matching)
C57BL/6N-Map3k7tm1c(EUCOMM)Wtsi/H
| Status | Under development - register interest |
| EMMA ID | EM:16783 |
| Citation information | RRID:IMSR_EM:16783 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Map3k7tm1c(EUCOMM)Wtsi/H |
| Alternative name | C57BL/6N-Map3k7 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Map3k7tm1(EUCOMM)Wtsi |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone EPD0765_1_B11, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal vascular regression / MGI
- microcephaly / MGI
- short tail / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal blood vessel morphology / MGI
- decreased embryo size / MGI
- edema / MGI
- pericardial edema / MGI
- hemorrhage / MGI
- small heart / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal pharyngeal arch artery morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- thin myocardium compact layer / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal vascular smooth muscle morphology / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- absent fibroblast proliferation / MGI
- embryo tissue necrosis / MGI