IMPC phenotypes (gene matching)
C57BL/6N-Pink1tm1c(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:16785 |
| Citation information | RRID:IMSR_EM:16785 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Pink1tm1c(EUCOMM)Wtsi/H |
| Alternative name | C57BL/6N-Pink1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Pink1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Pink1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone EPD0787_2_G02, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Young-onset Parkinson disease / Orphanet_2828
MGI phenotypes (gene matching)
- abnormal cerebral cortex morphology / MGI
- decreased body weight / MGI
- abnormal social investigation / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- extended life span / MGI
- abnormal olfaction / MGI
- abnormal sensory capabilities/reflexes/nociception / MGI
- abnormal innervation / MGI
- abnormal nervous system electrophysiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- abnormal dopaminergic neuron morphology / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- oxidative stress / MGI
- abnormal neuron physiology / MGI
- abnormal lysosome morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- cellular phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased dopamine level / MGI
- abnormal mitochondrion morphology / MGI
- abnormal mitochondrial physiology / MGI
- increased interleukin-1 beta secretion / MGI
- increased interleukin-10 secretion / MGI
- increased interleukin-12 secretion / MGI
- increased sensitivity to induced cell death / MGI
- abnormal olfactory bulb glomerular layer morphology / MGI
- abnormal cellular respiration / MGI
- abnormal respiratory electron transport chain / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI