C57BL/6NTac-Cisd2tm1b(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:16801
Citation informationRRID:IMSR_EM:16801 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Cisd2tm1b(EUCOMM)Wtsi/H
Alternative nameC57BL/6NTac-Cisd2/H
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCisd2tm1b(EUCOMM)Wtsi
Gene/Transgene symbolCisd2

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from ESC clone EPD0143_2_C03. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele . For further details on the construction of this clone see the page at the IMPC portal
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal eye size / IMPC
  • abnormal behavior / IMPC
  • decreased bone mineral density / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal glucose homeostasis / IMPC
  • increased circulating phosphate level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased lean body mass / IMPC
  • decreased heart weight / IMPC
  • decreased circulating amylase level / IMPC
  • increased lean body mass / IMPC
  • increased total body fat amount / IMPC
  • increased bone mineral content / IMPC
  • decreased circulating creatinine level / IMPC
  • decreased locomotor activity / IMPC
  • corneal vascularization / IMPC
MGI phenotypes (gene matching)
  • prominent ears / MGI
  • decreased bone mineral density / MGI
  • kyphosis / MGI
  • lordosis / MGI
  • decreased hair follicle number / MGI
  • ruffled hair / MGI
  • tremors / MGI
  • weakness / MGI
  • muscle degeneration / MGI
  • abnormal skeletal muscle morphology / MGI
  • demyelination / MGI
  • thick epidermis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • corneal opacity / MGI
  • abnormal optic nerve morphology / MGI
  • postnatal growth retardation / MGI
  • blindness / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal glucose homeostasis / MGI
  • premature death / MGI
  • neurodegeneration / MGI
  • abnormal respiratory function / MGI
  • exophthalmos / MGI
  • impaired skeletal muscle contractility / MGI
  • increased insulin sensitivity / MGI
  • decreased insulin secretion / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • oliguria / MGI
  • premature aging / MGI
  • abnormal defecation / MGI
  • abnormal muscle fiber morphology / MGI
  • dilated sarcoplasmic reticulum / MGI
  • abnormal sarcomere morphology / MGI
  • abnormal calcium ion homeostasis / MGI
  • small thoracic cavity / MGI
  • lethargy / MGI
  • decreased oxygen consumption / MGI
  • impaired glucose tolerance / MGI
  • abnormal myocardium layer morphology / MGI
  • muscle phenotype / MGI
  • axon degeneration / MGI
  • decreased tidal volume / MGI
  • abnormal mitochondrion morphology / MGI
  • decreased body mass index / MGI
  • abnormal autophagy / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • retinal neovascularization / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • decreased total body fat amount / MGI
  • abnormal respiratory electron transport chain / MGI
  • increased mitochondria size / MGI
  • abnormal mitochondrial shape / MGI
  • abnormal mitochondrial crista morphology / MGI
  • decreased food intake / MGI
  • decreased fluid intake / MGI

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