C57BL/6N-A^tm1Brd Clpp^{tm1b(EUCOMM)Wtsi}/WtsiH

Status	Under development - register interest
EMMA ID	EM:16805
Citation information	RRID:IMSR_EM:16805 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-A^tm1Brd Clpp^{tm1b(EUCOMM)Wtsi}/WtsiH
Alternative name	C57BL/6N-A Clpp/WtsiH
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Clpp^{tm1b(EUCOMM)Wtsi}
Gene/Transgene symbol	Clpp

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from ESC clone EPD0665_3_D05. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele . For further details on the construction of this clone see the page at the IMPC portal
Phenotypic information	Homozygous: These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org Heterozygous: These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Perrault syndrome / Orphanet_2855

IMPC phenotypes (gene matching)

thrombocytopenia / IMPC
increased circulating bilirubin level / IMPC
decreased lean body mass / IMPC
increased leukocyte cell number / IMPC
increased circulating cholesterol level / IMPC
increased mean corpuscular hemoglobin / IMPC
increased monocyte cell number / IMPC
increased Ly6C low monocyte number / IMPC
decreased bone mineral content / IMPC
decreased circulating fructosamine level / IMPC
increased lean body mass / IMPC
increased KLRG1-positive NK cell number / IMPC
increased circulating glycerol level / IMPC
decreased total body fat amount / IMPC
decreased NK T cell number / IMPC
decreased memory-marker CD4-positive NK T cell number / IMPC
decreased body length / IMPC
increased hemoglobin content / IMPC
increased total body fat amount / IMPC
increased mature B cell number / IMPC
decreased bone mineral density / IMPC
decreased circulating glucose level / IMPC
increased circulating serum albumin level / IMPC
increased B cell number / IMPC
abnormal bone structure / IMPC
tremors / IMPC
increased circulating iron level / IMPC
decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
abnormal auditory brainstem response / IMPC
increased Ly6C high monocyte number / IMPC
female infertility / IMPC
decreased CD4-positive NK T cell number / IMPC
decreased red blood cell distribution width / IMPC
increased circulating aspartate transaminase level / IMPC
increased hematocrit / IMPC
decreased memory-marker CD4-negative NK T cell number / IMPC
increased circulating alkaline phosphatase level / IMPC
male infertility / IMPC
decreased gamma-delta T cell number / IMPC

MGI phenotypes (gene matching)

decreased cell proliferation / MGI
small ovary / MGI
small testis / MGI
arrest of spermatogenesis / MGI
dermatitis / MGI
decreased body length / MGI
hypoactivity / MGI
decreased startle reflex / MGI
abnormal T cell activation / MGI
male infertility / MGI
female infertility / MGI
abnormal oogenesis / MGI
premature death / MGI
decreased corpora lutea number / MGI
decreased vertical activity / MGI
azoospermia / MGI
early cellular replicative senescence / MGI
abnormal granulosa cell morphology / MGI
decreased susceptibility to weight gain / MGI
abnormal cellular respiration / MGI
preweaning lethality, incomplete penetrance / MGI
increased mitochondria size / MGI
disorganized mitochondrial cristae / MGI
abnormal mitochondrial chromosome morphology / MGI
abnormal seminiferous tubule epithelium morphology / MGI
increased embryonic tissue cell apoptosis / MGI
increased granulosa cell apoptosis / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Atm1Brd Clpptm1b(EUCOMM)Wtsi/WtsiH