C57BL/6N-Malt1tm1b(EUCOMM)Hmgu/H

Status

Under development - register interest

EMMA IDEM:16809
Citation informationRRID:IMSR_EM:16809 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Malt1tm1b(EUCOMM)Hmgu/H
Alternative nameC57BL/6N-Malt1/H
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMalt1tm1b(EUCOMM)Hmgu
Gene/Transgene symbolMalt1

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from ESC clone HEPD0618_3_A10. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele . For further details on the construction of this clone see the page at the IMPC portal
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal immune system morphology / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal double-negative T cell morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • absent B-1a cells / MGI
  • decreased interleukin-2 secretion / MGI
  • impaired humoral immune response / MGI

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Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

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