- increased circulating triglyceride level / IMPC
- decreased bone mineral content / IMPC
- increased circulating calcium level / IMPC
- abnormal retina morphology / IMPC
- increased total body fat amount / IMPC
- decreased bone mineral density / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- increased circulating phosphate level / IMPC
C57BL/6N-Txniptm1c(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:16815 |
| Citation information | RRID:IMSR_EM:16815 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Txniptm1c(EUCOMM)Hmgu/H |
| Alternative name | C57BL/6N-Txnip |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Txniptm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Txnip |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone HEPD0732_5_F08, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- abnormal circulating insulin level / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- no abnormal phenotype detected / MGI
- increased circulating ketone body level / MGI
- abnormal ileum morphology / MGI
- hepatic steatosis / MGI
- increased insulin sensitivity / MGI
- increased liver weight / MGI
- liver degeneration / MGI
- increased hepatocellular carcinoma incidence / MGI
- abnormal gluconeogenesis / MGI
- kidney failure / MGI
- abnormal heart left ventricle morphology / MGI
- impaired cellular glucose import / MGI
- altered response of heart to induced stress / MGI
- increased regulatory T cell number / MGI
- increased lymphocyte cell number / MGI
- abnormal NK cell morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- hematuria / MGI
- increased circulating cholesterol level / MGI
- abnormal mesenteric lymph node morphology / MGI
- increased fatty acid level / MGI
- improved glucose tolerance / MGI
- increased T cell proliferation / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- reproductive system phenotype / MGI
- decreased circulating glucose level / MGI
- increased blood urea nitrogen level / MGI
- decreased ventricle muscle contractility / MGI
- increased bleeding time / MGI
- increased circulating potassium level / MGI
- decreased circulating sodium level / MGI
- abnormal circulating phospholipid level / MGI
- decreased NK T cell number / MGI
- decreased NK cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal blood homeostasis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- mortality/aging / MGI
- abnormal cellular respiration / MGI
- decreased circulating antithrombin level / MGI
- increased prothrombin time / MGI
- increased partial thromboplastin time / MGI
- increased circulating lactate level / MGI
- increased cardiac cell glucose uptake / MGI
- increased muscle cell glucose uptake / MGI
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