C57BL/6NTac-Plcg2tm1c(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:16819
Citation informationRRID:IMSR_EM:16819 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Plcg2tm1c(EUCOMM)Hmgu/H
Alternative nameC57BL/6NTac-Plcg2/H
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPlcg2tm1c(EUCOMM)Hmgu
Gene/Transgene symbolPlcg2

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from ESC clone HEPD0636_2_D02, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
    • Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
IMPC phenotypes (gene matching)
  • increased T cell number / IMPC
  • hyperactivity / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal glucose homeostasis / IMPC
  • thrombocytosis / IMPC
  • decreased hematocrit / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased IgG3 level / IMPC
  • decreased mature B cell number / IMPC
  • decreased circulating free fatty acids level / IMPC
  • increased IgM level / IMPC
  • increased IgG1 level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased bone mineral density / IMPC
  • increased IgG2b level / IMPC
  • decreased erythrocyte cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal foot pad morphology / MGI
  • spleen hyperplasia / MGI
  • dermatitis / MGI
  • internal hemorrhage / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • abnormal inflammatory response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • chronic inflammation / MGI
  • glomerulonephritis / MGI
  • increased pre-B cell number / MGI
  • decreased susceptibility to induced arthritis / MGI
  • osteoarthritis / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased B-1a cell number / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased B cell apoptosis / MGI
  • increased trabecular bone thickness / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal NK cell physiology / MGI
  • increased trabecular bone volume / MGI
  • chylous ascites / MGI

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