C57BL/6N-Nrxn1tm1c(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:16821
Citation informationRRID:IMSR_EM:16821 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Nrxn1tm1c(KOMP)Wtsi/H
Alternative nameC57BL/6N-Nrxn1/H
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolNrxntm1c(KOMP)Wtsi
Gene/Transgene symbolNrxn1

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from ESC clone EPD0796_5_E08, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationHomozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org

Heterozygous:
These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Pitt-Hopkins-like syndrome / Orphanet_221150
    • NRXN1-related severe neurodevelopmental disorder-motor stereotypies-chronic constipation-sleep-wake cycle disturbance / Orphanet_600663
IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • tremors / IMPC
  • increased circulating amylase level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased grip strength / IMPC
  • decreased pulmonary respiratory rate / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased total body fat amount / IMPC
  • decreased circulating total protein level / IMPC
  • decreased circulating serum albumin level / IMPC
  • impaired glucose tolerance / IMPC
  • decreased fasting circulating glucose level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased lean body mass / IMPC
  • increased circulating aspartate transaminase level / IMPC
MGI phenotypes (gene matching)
  • increased grooming behavior / MGI
  • abnormal nest building behavior / MGI
  • no abnormal phenotype detected / MGI
  • abnormal motor learning / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • abnormal nervous system physiology / MGI
  • decreased synaptic glutamate release / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased prepulse inhibition / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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EMMA conditions
Legally binding conditions for the transfer

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