IMPC phenotypes (gene matching)
C57BL/6N-Otptm1c(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:16823 |
| Citation information | RRID:IMSR_EM:16823 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Otptm1c(EUCOMM)Wtsi/H |
| Alternative name | C57BL/6N-Otp |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Otptm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Otp |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This line originates from ESC clone EPD0792_1_H12, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased brain size / MGI
- abnormal third ventricle morphology / MGI
- abnormal diencephalon morphology / MGI
- abnormal hypothalamus morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal dopaminergic neuron morphology / MGI
- abnormal neurohypophysis morphology / MGI
- abnormal hypothalamus physiology / MGI
- abnormal paraventricular hypothalamic nucleus morphology / MGI
- abnormal supraoptic nucleus morphology / MGI
- abnormal neurohypophysis median eminence morphology / MGI
- postnatal lethality, complete penetrance / MGI