C57BL/6N-Il12atm1b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16852
Citation informationRRID:IMSR_EM:16852 

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International strain nameC57BL/6N-Il12atm1b(EUCOMM)Hmgu/H
Alternative nameHEPD0634_3_C09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolIl12atm1b(EUCOMM)Hmgu
Gene/Transgene symbolIl12a
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0634_3_C09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating HDL cholesterol level / IMPC
  • vertebral fusion / IMPC
IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • vertebral fusion / IMPC
MGI phenotypes (gene matching)
  • increased incidence of tumors by chemical induction / MGI
  • increased susceptibility to parasitic infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased circulating interleukin-12 level / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
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