C57BL/6N-Tnip1tm1b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16876
Citation informationRRID:IMSR_EM:16876 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Tnip1tm1b(EUCOMM)Hmgu/H
Alternative nameHEPD0510_7_F09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTnip1tm1b(EUCOMM)Hmgu
Gene/Transgene symbolTnip1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0510_7_F09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased hematocrit / IMPC
  • increased monocyte cell number / IMPC
  • increased mean platelet volume / IMPC
  • increased basophil cell number / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating iron level / IMPC
  • increased spleen weight / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating glucose level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased circulating potassium level / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased circulating fructosamine level / IMPC
  • prolonged RR interval / IMPC
  • increased large unstained cell number / IMPC
  • increased freezing behavior / IMPC
IMPC phenotypes (gene matching)
  • increased circulating aspartate transaminase level / IMPC
  • increased red blood cell distribution width / IMPC
  • increased mean platelet volume / IMPC
  • decreased circulating glucose level / IMPC
  • increased spleen weight / IMPC
  • decreased circulating triglyceride level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased large unstained cell number / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • increased freezing behavior / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating fructosamine level / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased lymphocyte cell number / IMPC
  • prolonged RR interval / IMPC
  • decreased hemoglobin content / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased circulating iron level / IMPC
  • increased circulating potassium level / IMPC
  • decreased hematocrit / IMPC
  • increased monocyte cell number / IMPC
  • increased basophil cell number / IMPC
  • decreased erythrocyte cell number / IMPC

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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