C57BL/6N-Ctsatm2b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16891
Citation informationRRID:IMSR_EM:16891 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Ctsatm2b(EUCOMM)Hmgu/H
Alternative nameHEPD0507_5_A09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCtsatm2b(EUCOMM)Hmgu
Gene/Transgene symbolCtsa
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0507_5_A09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating calcium level / IMPC
  • decreased hematocrit / IMPC
  • increased monocyte cell number / IMPC
  • abnormal head morphology / IMPC
  • abnormal forelimb morphology / IMPC
  • abnormal hindlimb morphology / IMPC
  • enlarged spleen / IMPC
  • tremors / IMPC
  • abnormal locomotor behavior / IMPC
  • decreased locomotor activity / IMPC
  • abnormal gait / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal startle reflex / IMPC
  • decreased startle reflex / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased circulating triglyceride level / IMPC
  • increased heart weight / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • increased spleen weight / IMPC
  • decreased circulating cholesterol level / IMPC
  • narrow eye opening / IMPC
  • decreased heart rate / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating glucose level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased circulating total protein level / IMPC
  • increased circulating potassium level / IMPC
  • increased circulating iron level / IMPC
  • decreased prepulse inhibition / IMPC
  • impaired cued conditioning behavior / IMPC
  • prolonged RR interval / IMPC
  • abnormal freezing behavior / IMPC
  • increased freezing behavior / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating glucose level / IMPC
  • increased freezing behavior / IMPC
  • decreased circulating calcium level / IMPC
  • abnormal gait / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal head morphology / IMPC
  • impaired cued conditioning behavior / IMPC
  • abnormal locomotor behavior / IMPC
  • decreased locomotor activity / IMPC
  • narrow eye opening / IMPC
  • increased circulating iron level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal startle reflex / IMPC
  • increased spleen weight / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased hemoglobin content / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased monocyte cell number / IMPC
  • increased mean corpuscular volume / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased circulating cholesterol level / IMPC
  • thrombocytopenia / IMPC
  • tremors / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating potassium level / IMPC
  • decreased circulating total protein level / IMPC
  • abnormal freezing behavior / IMPC
  • prolonged RR interval / IMPC
  • enlarged spleen / IMPC
  • decreased hematocrit / IMPC
  • decreased heart rate / IMPC
  • increased circulating bilirubin level / IMPC
  • abnormal forelimb morphology / IMPC
  • decreased startle reflex / IMPC
  • decreased circulating serum albumin level / IMPC
  • abnormal hindlimb morphology / IMPC
  • increased heart weight / IMPC

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Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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