C57BL/6N-Elmod1^{tm1b(EUCOMM)Hmgu}/H

Status	Only small colony available
EMMA ID	EM:16907
Citation information	RRID:IMSR_EM:16907 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Elmod1^{tm1b(EUCOMM)Hmgu}/H
Alternative name	HEPD0557_4_E10
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Elmod1^{tm1b(EUCOMM)Hmgu}
Gene/Transgene symbol	Elmod1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Mary Lyon Centre at MRC Harwell
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0557_4_E10. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (C57BL/6NTac-Tg(ACTB-cre)3Mrt/H). Click here for more information on EUCOMM final vectors.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased leukocyte cell number / IMPC
decreased monocyte cell number / IMPC
tremors / IMPC
abnormal iris morphology / IMPC
decreased anxiety-related response / IMPC
abnormal locomotor behavior / IMPC
hyperactivity / IMPC
decreased locomotor activity / IMPC
abnormal gait / IMPC
head bobbing / IMPC
abnormal startle reflex / IMPC
decreased startle reflex / IMPC
trunk curl / IMPC
increased circulating phosphate level / IMPC
abnormal ear morphology / IMPC
increased mean corpuscular volume / IMPC
increased heart weight / IMPC
increased kidney weight / IMPC
increased heart rate variability / IMPC
increased lean body mass / IMPC
abnormal auditory brainstem response / IMPC
abnormal behavior / IMPC
decreased spleen weight / IMPC
increased eosinophil cell number / IMPC
decreased lymphocyte cell number / IMPC
cardiovascular system phenotype / IMPC
increased mean corpuscular hemoglobin / IMPC
increased blood urea nitrogen level / IMPC
decreased prepulse inhibition / IMPC
decreased total body fat amount / IMPC
decreased grip strength / IMPC
increased red blood cell distribution width / IMPC
shortened PR interval / IMPC
shortened PQ interval / IMPC
decreased large unstained cell number / IMPC
decreased thigmotaxis / IMPC

IMPC phenotypes (gene matching)

hyperactivity / IMPC
decreased prepulse inhibition / IMPC
abnormal locomotor behavior / IMPC
abnormal auditory brainstem response / IMPC
abnormal behavior / IMPC
increased startle reflex / IMPC
shortened PQ interval / IMPC
increased lean body mass / IMPC
decreased lymphocyte cell number / IMPC
decreased leukocyte cell number / IMPC
decreased thigmotaxis / IMPC
thrombocytopenia / IMPC
abnormal ear morphology / IMPC
decreased circulating glycerol level / IMPC
decreased large unstained cell number / IMPC
decreased locomotor activity / IMPC
abnormal startle reflex / IMPC
decreased circulating cholesterol level / IMPC
head bobbing / IMPC
abnormal gait / IMPC
decreased circulating HDL cholesterol level / IMPC
decreased anxiety-related response / IMPC
abnormal glucose homeostasis / IMPC
impaired pupillary reflex / IMPC
decreased grip strength / IMPC
increased circulating phosphate level / IMPC
increased red blood cell distribution width / IMPC
trunk curl / IMPC
increased circulating chloride level / IMPC
increased blood urea nitrogen level / IMPC
increased eosinophil cell number / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal response to tactile stimuli / IMPC
decreased B cell number / IMPC
abnormal locomotor activation / IMPC
tremors / IMPC
decreased monocyte cell number / IMPC
shortened PR interval / IMPC
decreased spleen weight / IMPC
decreased total body fat amount / IMPC
abnormal iris morphology / IMPC
increased heart rate variability / IMPC
increased mean corpuscular hemoglobin / IMPC
increased mean corpuscular volume / IMPC
cardiovascular system phenotype / IMPC
increased heart weight / IMPC
decreased startle reflex / IMPC
increased kidney weight / IMPC

MGI phenotypes (gene matching)

organ of Corti degeneration / MGI
circling / MGI
deafness / MGI
cochlear ganglion degeneration / MGI
abnormal cochlear hair cell stereociliary bundle morphology / MGI
hearing/vestibular/ear phenotype / MGI
absent startle reflex / MGI
increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H