IMPC phenotypes (allele matching)
C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
| Status | Only small colony available |
| EMMA ID | EM:16910 |
| Citation information | RRID:IMSR_EM:16910 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H |
| Alternative name | EPD0156_3_A04 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Gna11tm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Gna11 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0156_3_A04. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Phakomatosis cesioflammea / Orphanet_79483
- Phakomatosis cesiomarmorata / Orphanet_79484
- Uveal melanoma / Orphanet_39044
- Familial hypocalciuric hypercalcemia type 2 / Orphanet_101049
- Autosomal dominant hypocalcemia / Orphanet_428
IMPC phenotypes (gene matching)
- decreased circulating phosphate level / IMPC
- decreased erythrocyte cell number / IMPC
- decreased hemoglobin content / IMPC
- decreased mean corpuscular volume / IMPC
- decreased bone mineral density / IMPC
- increased circulating alanine transaminase level / IMPC
- increased circulating calcium level / IMPC
- increased startle reflex / IMPC
- increased red blood cell distribution width / IMPC
- vertebral fusion / IMPC
- decreased hematocrit / IMPC
- increased bone mineral content / IMPC
- abnormal behavior / IMPC
- decreased circulating triglyceride level / IMPC
- decreased circulating amylase level / IMPC
- thrombocytopenia / IMPC
MGI phenotypes (gene matching)
- increased foot pad pigmentation / MGI
- hyperpigmentation / MGI
- increased circulating triglyceride level / MGI
- hepatic steatosis / MGI
- nervous system phenotype / MGI
- darkened coat color / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- increased liver triglyceride level / MGI
- increased tail pigmentation / MGI
- increased ear pigmentation / MGI