C57BL/6NCrl-Pmp22em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:16955
Citation informationRRID:IMSR_EM:16955 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Pmp22em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPmp22em1(IMPC)Ccpcz
Gene/Transgene symbolPmp22

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • tremors / MGI
  • muscle weakness / MGI
  • muscle degeneration / MGI
  • hindlimb paralysis / MGI
  • forelimb paralysis / MGI
  • abnormal myelination / MGI
  • demyelination / MGI
  • convulsive seizures / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal Schwann cell morphology / MGI
  • decreased body size / MGI
  • ataxia / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • limb grasping / MGI
  • abnormal motor coordination/balance / MGI
  • impaired righting response / MGI
  • postnatal growth retardation / MGI
  • reduced male fertility / MGI
  • deafness / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • postnatal lethality / MGI
  • abnormal sexual interaction / MGI
  • abnormal neuron morphology / MGI
  • increased circulating alkaline phosphatase level / MGI
  • abnormal myelin sheath morphology / MGI
  • limbs/digits/tail phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal action potential / MGI
  • abnormal axon morphology / MGI
  • axon degeneration / MGI
  • abnormal cell physiology / MGI
  • impaired hearing / MGI
  • abnormal autophagy / MGI
  • decreased survivor rate / MGI
  • decreased nerve conduction velocity / MGI
  • decreased grip strength / MGI
  • mortality/aging / MGI
  • lethality at weaning, complete penetrance / MGI
  • abnormal Schwann cell physiology / MGI
  • increased Schwann cell proliferation / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • spasticity / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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