MGI phenotypes (allele matching)
NOD.B6-(D6Mit254-D6Mit14)/Orl
| Status | Available to order |
| EMMA ID | EM:01711 |
| International strain name | NOD.B6-(D6Mit254-D6Mit14)/Orl |
| Alternative name | NOD.B6-NK1.1 |
| Strain type | Other |
| Allele/Transgene symbol | Klrb1ca, |
| Gene/Transgene symbol | Klrb1c |
Information from provider
| Provider | HERBELIN HERBELIN |
| Provider affiliation | CNRS UMR 8147 |
| Genetic information | NOD congenic strain with the distal portion of chromosome 6 from C57BL/6. |
| Phenotypic information | The B6 region introgressed in the NOD background contains the susceptibility locus Idd6 and the Klrb1c (NKR-P1) gene cluster. This region controls the severity of diabetes and natural killer (NK) and NKT cell functions. The Klrb1ca (NK1.1) congenic mouse strain may be used for easier experimental identification of NKT cells in NOD mice. |
| Breeding history | 10 generations of backcross followed by sister-brother matings. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex.;Carnaud C, Gombert J, Donnars O, Garchon H, Herbelin A, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;2404-11; 11160299