B6;129S7-Prnptm1Cwe Tg(Alb1-Prnp)19Cwe/CweCnrm

Status

Available to order

EMMA IDEM:00177
International strain nameB6;129S7-Prnptm1Cwe Tg(Alb1-Prnp)19Cwe/CweCnrm
Alternative nameTg19/Alb
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Alb1-Prnp)19Cwe,
Gene/Transgene symbolTg(Alb1-Prnp)19Cwe

Information from provider

ProviderAdriano Aguzzi
Provider affiliationUniv.Hosp.Zurich/Inst.Neuropathology
Genetic informationHepatocyte-specific expression of Prnp (PrP) on Prnp-/- background. Introduction of half genomic PrP transgene driven by albumin promoter (copy number 2). Homozygous breeding.
References
  • Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication.;Raeber A J, Sailer A, Hegyi I, Klein M A, Rülicke T, Fischer M, Brandner S, Aguzzi A, Weissmann C, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;3987-92; 10097150

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term potentiation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased brain copper level / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • decreased Purkinje cell number / MGI

Literature references

  • Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication.;Raeber A J, Sailer A, Hegyi I, Klein M A, Rülicke T, Fischer M, Brandner S, Aguzzi A, Weissmann C, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;3987-92; 10097150

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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