B6.129P2-Mapk8tm1Wag/Kctt

Status

Available to order

EMMA IDEM:01772
International strain nameB6.129P2-Mapk8tm1Wag/Kctt
Alternative nameJnk1-C57Bl6
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMapk8tm1Wag,
Gene/Transgene symbolMapk8

Information from provider

ProviderIngrid Fossar-Larsen
Provider affiliationDepartment of Molecular Cancer Biology, Danish Cancer Society
Genetic informationThe Mapk8 (Jnk1) gene is disrupted by insertion of the lacZ cassette at the first exon. This mutation inactivates all known Mapk8 splicing variants.
Phenotypic informationNo major defects. Defects in T-cell apoptosis and proliferation. Mice are resistant to type 2 diabetes.
References
  • c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.;Sabapathy K, Kallunki T, David J P, Graef I, Karin M, Wagner E F, ;2001;The Journal of experimental medicine;193;317-28; 11157052
  • A central role for JNK in obesity and insulin resistance.;Hirosumi Jiro, Tuncman Gürol, Chang Lufen, Görgün Cem Z, Uysal K Teoman, Maeda Kazuhisa, Karin Michael, Hotamisligil Gökhan S, ;2002;Nature;420;333-6; 12447443
  • JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.;Chang Lufen, Jones Ying, Ellisman Mark H, Goldstein Lawrence S B, Karin Michael, ;2003;Developmental cell;4;521-33; 12689591
  • Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector.;Björkblom Benny, Ostman Nina, Hongisto Vesa, Komarovski Vladislav, Filén Jan-Jonas, Nyman Tuula A, Kallunki Tuula, Courtney Michael J, Coffey Eleanor T, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;6350-61; 16000625

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • improved glucose tolerance / MGI
  • decreased circulating glucose level / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal fat cell morphology / MGI
  • increased epididymal fat pad weight / MGI
  • decreased total body fat amount / MGI
  • abnormal T cell activation / MGI
  • decreased T cell proliferation / MGI
  • decreased T cell apoptosis / MGI

Literature references

  • c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.;Sabapathy K, Kallunki T, David J P, Graef I, Karin M, Wagner E F, ;2001;The Journal of experimental medicine;193;317-28; 11157052
  • A central role for JNK in obesity and insulin resistance.;Hirosumi Jiro, Tuncman Gürol, Chang Lufen, Görgün Cem Z, Uysal K Teoman, Maeda Kazuhisa, Karin Michael, Hotamisligil Gökhan S, ;2002;Nature;420;333-6; 12447443
  • JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.;Chang Lufen, Jones Ying, Ellisman Mark H, Goldstein Lawrence S B, Karin Michael, ;2003;Developmental cell;4;521-33; 12689591
  • Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector.;Björkblom Benny, Ostman Nina, Hongisto Vesa, Komarovski Vladislav, Filén Jan-Jonas, Nyman Tuula A, Kallunki Tuula, Courtney Michael J, Coffey Eleanor T, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;6350-61; 16000625

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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