NMRI-Tg(WAP-TAg)12Gmn/Kctt
| Status | Available to order |
| EMMA ID | EM:01786 |
| Citation information | RRID:IMSR_EM:01786 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | NMRI-Tg(WAP-TAg)12Gmn/Kctt |
| Alternative name | WAP-SVT |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Wap-TAg)12Gmn |
| Gene/Transgene symbol | Tg(Wap-TAg)12Gmn |
Information from provider
| Provider | Adolf Graessmann |
| Provider affiliation | Institut für Molekularbiologie und Biochemie |
| Genetic information | Large T-antigen (outside of the early SV40 coding region) under transcription control of WAP (whey acidic protein) promoter. |
| Phenotypic information | Breast cancer formation. |
| Breeding history | Animals were generated in 1998 and continuously propagated. The transgene is kept at heterozygous state. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Literature references
- The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.;Goetz F, Tzeng Y J, Guhl E, Merker J, Graessmann M, Graessmann A, ;2001;Oncogene;20;2325-32; 11402328