B10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H

Status

Available to order

EMMA IDEM:01892
International strain nameB10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H
Alternative namePlcg2-383/Bcl2-36Tg
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Igh2k3-83)1Nemz,
Gene/Transgene symbolTg(Igh23-83)1Nemz

Information from provider

ProviderMartin Turner
Provider affiliationThe Babraham Institute, Babraham, Cambridge, CB2 4PB
Genetic informationThese mice have a null mutation in Plcg2 and display defects in B-lymphocyte function. They also contain a transgene encoding a specific B-cell receptor and a transgene that directs expression of the anti-apoptotic protein Bcl2 to both B- and T-cells.
Phenotypic informationDefects in B-lymphocyte development. High incidence of perinatal lethality. Homozygotes are infertile.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
    • Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
MGI phenotypes (allele matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • abnormal cytokine secretion / MGI
  • increased autoantibody level / MGI
  • decreased susceptibility to parasitic infection / MGI
  • arrested B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal B cell physiology / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased B cell proliferation / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased mature B cell number / MGI
  • increased B cell apoptosis / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal B cell differentiation / MGI
  • increased susceptibility to viral infection / MGI
  • increased pre-B cell number / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased B cell proliferation / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased interferon-gamma secretion / MGI
  • increased trabecular bone thickness / MGI
  • increased trabecular bone volume / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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