- decreased hematocrit / MGI
- abnormal liver physiology / MGI
- abnormal T cell differentiation / MGI
- abnormal cytokine secretion / MGI
- increased autoantibody level / MGI
- decreased susceptibility to parasitic infection / MGI
- arrested B cell differentiation / MGI
- abnormal dendritic cell physiology / MGI
- abnormal B cell physiology / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased B cell proliferation / MGI
- abnormal dendritic cell morphology / MGI
- decreased follicular B cell number / MGI
- increased pro-B cell number / MGI
- decreased mature B cell number / MGI
- increased B cell apoptosis / MGI
- decreased platelet aggregation / MGI
- increased transitional stage T2 B cell number / MGI
- abnormal dendritic cell chemotaxis / MGI
- abnormal trabecular bone morphology / MGI
- abnormal B cell differentiation / MGI
- increased susceptibility to viral infection / MGI
- increased pre-B cell number / MGI
- decreased osteoclast cell number / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- increased B cell proliferation / MGI
- abnormal osteoclast differentiation / MGI
- decreased interferon-gamma secretion / MGI
- increased trabecular bone thickness / MGI
- increased trabecular bone volume / MGI
B10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H
Status | Available to order |
EMMA ID | EM:01892 |
International strain name | B10.Cg-Plcg2tm1Jni H2d Tg(BCL2)36Wehi Tg(Igh2k3-83)1Nemz/H |
Alternative name | Plcg2 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Igh2k3-83)1Nemz, |
Gene/Transgene symbol | Tg(Igh2 |
Information from provider
Provider | Martin Turner |
Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
Genetic information | These mice have a null mutation in Plcg2 and display defects in B-lymphocyte function. They also contain a transgene encoding a specific B-cell receptor and a transgene that directs expression of the anti-apoptotic protein Bcl2 to both B- and T-cells. |
Phenotypic information | Defects in B-lymphocyte development. High incidence of perinatal lethality. Homozygotes are infertile. |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
- Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
MGI phenotypes (allele matching)
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